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LOCUS WP_003084250 760 aa linear BCT 23-DEC-2024 cyclase/phosphodiesterase [Pseudomonas]. ACCESSION WP_003084250 VERSION WP_003084250.1 KEYWORDS RefSeq. SOURCE Pseudomonas ORGANISM Pseudomonas Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae. REFERENCE 1 (residues 1 to 760) AUTHORS Romling,U. and Amikam,D. TITLE Cyclic di-GMP as a second messenger JOURNAL Curr Opin Microbiol 9 (2), 218-228 (2006) PUBMED 16530465 REFERENCE 2 (residues 1 to 760) AUTHORS Romling,U., Gomelsky,M. and Galperin,M.Y. TITLE C-di-GMP: the dawning of a novel bacterial signalling system JOURNAL Mol Microbiol 57 (3), 629-639 (2005) PUBMED 16045609 REFERENCE 3 (residues 1 to 760) AUTHORS Simm,R., Morr,M., Kader,A., Nimtz,M. and Romling,U. TITLE GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility JOURNAL Mol Microbiol 53 (4), 1123-1134 (2004) PUBMED 15306016 REFERENCE 4 (residues 1 to 760) AUTHORS Galperin,M.Y., Nikolskaya,A.N. and Koonin,E.V. TITLE Novel domains of the prokaryotic two-component signal transduction systems JOURNAL FEMS Microbiol Lett 203 (1), 11-21 (2001) PUBMED 11557134 REMARK Erratum:[FEMS Microbiol Lett 2001 Oct 16;204(1):213-4] COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11472025 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..760 /organism="Pseudomonas" /db_xref="taxon:286" Protein 1..760 /product="putative bifunctional diguanylate cyclase/phosphodiesterase" /EC_number="2.7.7.65" /GO_component="GO:0005886 - plasma membrane [Evidence IEA]" /GO_function="GO:0005525 - GTP binding [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_function="GO:0052621 - diguanylate cyclase activity [Evidence IEA]" /GO_function="GO:0071111 - cyclic-guanylate-specific phosphodiesterase activity [Evidence IEA]" /calculated_mol_wt=86250 Region 86..749 /region_name="COG5001" /note="Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms]" /db_xref="CDD:444025" ORIGIN 1 msprlsalrl slaylaiaia waflsdhllq nqvqdhdqlv fwmtakrlff faatglllyl 61 ylvrqfrrka qaydelhgse qrlnraleav rdglwdwdlv tdrmfvspgy aaliglapee 121 lgdpietwkk rlhpeeyatv leahrnhlqg ltdnldhiyr lrhkdgdyrw ihsrgrvlrd 181 algkplhytg varditlqrl kedhlrqaaa vfdstregvl vtdaqavivh vnpsferitg 241 yrsedvlgkt pailrsgrqd qafyqrlwla lreqdvwsge iwnrrksgei ypqwlhirav 301 rndqgqlthy vgvfsdlssi krseneldfl ahhdsltglp nrvllrerie qalengkdrt 361 vagalllidl dhfkhindsl ghttgdmllk evskrlqhql dercllsrlg gdefailven 421 ddpeavarls qrildgfnap fdihcqpiyi saslgvslyp edasdvdhlm qhadaalfqa 481 kdsgrnayaf ytrvltarar ahvqvesalr halehdelrv hyqpvhdlas grivgveslv 541 rwqhperglv ppgefvpvae ecgliaaldn wvlkracrqm rewqqrgvel efvavnvssr 601 lfnrggleer ianaleesgl eprylelevt esavmedfeq slnllcrlri lgvnlaiddf 661 gtgysslmrl krlpvhklki dqgfvaglpg avddaaiara ivalaqsmgl rvvaegiehq 721 dqalflrehg cdfgqgywyg rpqpaealrf dlppvalped