MULTISPECIES: MDR family MFS transporter [Pseudomonas].

LOCUS       WP_003082692             452 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_003082692
VERSION     WP_003082692.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Kumar,S., He,G., Kakarla,P., Shrestha,U., Ranjana,K.C.,
            Ranaweera,I., Willmon,T.M., Barr,S.R., Hernandez,A.J. and
            Varela,M.F.
  TITLE     Bacterial Multidrug Efflux Pumps of the Major Facilitator
            Superfamily as Targets for Modulation
  JOURNAL   Infect Disord Drug Targets 16 (1), 28-43 (2016)
   PUBMED   27052334
REFERENCE   3  (residues 1 to 452)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   4  (residues 1 to 452)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13025406
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..452
                     /product="MDR family MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=47034
     Region          11..441
                     /region_name="MFS_LmrB_MDR_like"
                     /note="Bacillus subtilis lincomycin resistance protein
                     (LmrB) and similar multidrug resistance (MDR) transporters
                     of the Major Facilitator Superfamily; cd17503"
                     /db_xref="CDD:341046"
     Site            order(18..19,22..23,26,58,108..109,111..113,116,136,
                     139..140,143,265,268..269,272..274,277,305,309,361..362,
                     366,370,386,389..390,393..394,397)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:341046"
ORIGIN      
        1 mnqpsrlatl yllgfaldlv nifiasvayp digrslgasv atlawignty llgltlvipl
       61 svwlasrlge rrlmllalag fasaslgcgl agsaatlivw rlcqglaggl liplgqamay
      121 rnvpasarag ltarvmlval ivpavapalg gwlvdslswr giffasvapa llvlalamrw
      181 lprhkhaaqr ldlrglllgs aalatllval awlgspgggg rglllallac vlgccywrdg
      241 rartdalldl glleapllrt amlvylcvpg afmganlvam lylqgplgls asragalmlp
      301 walaaglaig ltrrrfnrwg pkslllagma iqaggllwla rsgegsgfwq lagayatmgf
      361 ggslcssaaq gmalldvpaa rmghasalwn inrqlafclg mavlggllnl lqaradpaaf
      421 vhcflfaaaf tllplpwvrr idsagvralv qt