MULTISPECIES: MDR family MFS transporter [Pseudomonas].

LOCUS       WP_003082523             503 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_003082523
VERSION     WP_003082523.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Kumar,S., He,G., Kakarla,P., Shrestha,U., Ranjana,K.C.,
            Ranaweera,I., Willmon,T.M., Barr,S.R., Hernandez,A.J. and
            Varela,M.F.
  TITLE     Bacterial Multidrug Efflux Pumps of the Major Facilitator
            Superfamily as Targets for Modulation
  JOURNAL   Infect Disord Drug Targets 16 (1), 28-43 (2016)
   PUBMED   27052334
REFERENCE   3  (residues 1 to 503)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13025406
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..503
                     /product="MDR family MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=53837
     Region          19..487
                     /region_name="MFS_LmrB_MDR_like"
                     /note="Bacillus subtilis lincomycin resistance protein
                     (LmrB) and similar multidrug resistance (MDR) transporters
                     of the Major Facilitator Superfamily; cd17503"
                     /db_xref="CDD:341046"
     Site            order(25..26,29..30,33,65,115..116,118..120,123,143,
                     146..147,150,277,280..281,284..286,289,317,321,373..374,
                     378,382,398,401..402,405..406,409)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:341046"
ORIGIN      
        1 msaddkvslr awvavtgglf gcfmagmnvh vtsaalpeie galgatfeeg swistaylva
       61 eismipltaw lvevfslrrv mllgslvfll sslscalapn lstlilirvi qgasgavlip
      121 lsmqliltel pssriplgma lfslsnsvaq aagpsiggwl adayswrwif llqllpgial
      181 laavawsirp rdgdrerlrq adwlgigamv aglgalqivl eeggrrdwfe sgfirtfavl
      241 avlalllfvq rqlwgarpfi nlrllgsynf gvsslamavf gaatfglvfl vpnylsqlqg
      301 fnarqigdsl ilyglvqlll apllprlmrw lnpkllvagg faimalgcwm gahlnadagr
      361 nviipsivvr gigqplimva lsvlavkgld kaqagsasal ismlrnlgga igtalltqlv
      421 slrerfhser igetltifdg alqqrlgggq vriqlpeqqq alalldhgvr qqaylmaysd
      481 afylscvall acalaslmlr qkd