MULTISPECIES: multidrug effflux MFS transporter [Pseudomonas].

LOCUS       WP_003082230             385 aa            linear   BCT 20-NOV-2023
ACCESSION   WP_003082230
VERSION     WP_003082230.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 385)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 385)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022939
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..385
                     /product="multidrug effflux MFS transporter"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=40424
     Region          20..370
                     /region_name="MFS_MdfA_MDR_like"
                     /note="Multidrug transporter MdfA and similar multidrug
                     resistance (MDR) transporters of the Major Facilitator
                     Superfamily; cd17320"
                     /db_xref="CDD:340878"
     Site            order(20,23..24,48,51..52,109,140,143..144,225,228,344)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:340878"
ORIGIN      
        1 mpdrprppll lvlallalpq vaetilspal palashwrld datsqwtmal ffvgfapgiw
       61 lwgwladrlg rrpallgglg laalatfgaw astdysylla crlvqglgla tcsvtvqasl
      121 rdvlqgpalm syfvtlgavl awspavgplg gqwladlggh pavfatlavl laslaalvvp
      181 awpetrplla gtpepatlai frrvladrpl qtrallvavl nvlvfsfyaa gpfmvgdlpg
      241 lgfgwiglai aiagslgall nrrlprtwns arrvrlglal aaagataqtl laavgyaegl
      301 ywalpalpif igfgvaipnl lgpalhaydd crgragalfg layylliglg lgastllpfd
      361 rpwplaayws llglvallla rrlpe