MULTISPECIES: MFS transporter [Enterobacteriaceae].

LOCUS       WP_002923153             456 aa            linear   BCT 24-DEC-2024
ACCESSION   WP_002923153
VERSION     WP_002923153.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 456)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 456)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 456)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   4  (residues 1 to 456)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024277
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     Protein         1..456
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48672
     Region          26..436
                     /region_name="MFS_PcaK_like"
                     /note="4-hydroxybenzoate transporter PcaK and similar
                     transporters of the Major Facilitator Superfamily;
                     cd17365"
                     /db_xref="CDD:340923"
     Site            order(36..37,40..41,44,76,126..127,129..131,134,154,
                     157..158,161,265,268..269,272..274,277,304,308,358..359,
                     363,367,383,386..387,390..391,394)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340923"
ORIGIN      
        1 mnhtnvvdvk awidtrpvsr fqwnvlllcf iiimldgyda avmgfvapal iedwgisrae
       61 mgpilgaamf gvaigalvag plsdrygrkr illwsvalfa lfslagavaq sptqlalmrf
      121 ltglglgavm pncvtlvaey mperrkgvmi tlmysgfnvg sglggfiaag llshyswhsa
      181 lvfggvlplv vlpfmivmlp esamnmvarr lpgeqiaral nrlggqftae tvfqlnappi
      241 trsskvaqlf rhgyargtia lwltyfmglf viyllngwlp tilrsgglsl qqaammtglf
      301 qlggplggil vgmlmdrasa kaviaatyfl gclcllsqgv mdfgsaalsv lifisgmcin
      361 gaqnglqays payyqteira tgvswmhgig rtgailsstl ggmlmlavpg hssiflvlal
      421 paclagicil lhrmnhakpr lteaeldals splehr