MULTISPECIES: multidrug effflux MFS transporter

LOCUS       WP_002923107             387 aa            linear   BCT 22-DEC-2024
            [Enterobacteriaceae].
ACCESSION   WP_002923107
VERSION     WP_002923107.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 387)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 387)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022939
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     Protein         1..387
                     /product="multidrug effflux MFS transporter"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=41087
     Region          9..371
                     /region_name="MFS_MdfA_MDR_like"
                     /note="Multidrug transporter MdfA and similar multidrug
                     resistance (MDR) transporters of the Major Facilitator
                     Superfamily; cd17320"
                     /db_xref="CDD:340878"
     Site            order(19..20,23..24,48,51..52,109,140,143..144,223,226,
                     344)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:340878"
ORIGIN      
        1 marvslswal ilgllsgigp lctdfylpal peitqqlqat stqtqlslta aliglglgql
       61 ffgplsdrig rlkplalsll lfifssamca ltrdinmliv wrflqgfaga ggsvlsrsia
      121 rdkyqgtllt qffallmtvn giapvlspvl ggyvitafdw rilfwtmaai ggvllvmsla
      181 ilretrpata ahasrqrpgq pvlknrrflr fcliqafmma glfsyigsss fvmqseygms
      241 amqfsllfgl ngigliiaam ifsrlarrfs aesllrgglt lavscaaiml lfawlhlpvl
      301 alvglfftvs lmsgistvag aeamsavdaa qsgtasalmg tlmfvfggia aplaglgget
      361 mlkmslamai cyllalllgl skprdar