MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002921930             451 aa            linear   BCT 24-DEC-2024
ACCESSION   WP_002921930
VERSION     WP_002921930.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 451)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 451)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 451)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   4  (residues 1 to 451)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024277
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..451
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=47986
     Region          25..435
                     /region_name="MFS_PcaK_like"
                     /note="4-hydroxybenzoate transporter PcaK and similar
                     transporters of the Major Facilitator Superfamily;
                     cd17365"
                     /db_xref="CDD:340923"
     Site            order(35..36,39..40,43,75,125..126,128..130,133,153,
                     156..157,160,264,267..268,271..273,276,303,307,357..358,
                     362,366,382,385..386,389..390,393)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340923"
ORIGIN      
        1 mtkttidiqa finehpftry qwmilalcfi tvamdgfdta iigfiasdlv qewgveksal
       61 gpvmsaalvg lavgaltagp ladrigrkkv limsivvfgg fslltafats lnqltllrfl
      121 tglglgaamp naatlmseya perrrallvn lmfvgfpmgs slggflsawm iphygwqsvl
      181 vlggvmplll avalifllpe svrylvvkqh paqriaailr hiaplpktve fvlreagqvk
      241 eksaigvifs pryavgtvml cltyfmglli fylltswlpl liretgasms qasiitalfp
      301 lgggigvlil galmdkinpn kvvavgwllt gvfvclvgfs tsslalmgvm vfiagsimng
      361 aqssmpalaa gfyptqgrat gvawmlgigr fggilgafsg aflmqaqlsf etiftllaip
      421 aflsafalli kyrvsksvpa ttdearslqk a