MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002921927             426 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_002921927
VERSION     WP_002921927.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 426)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 426)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 426)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022908
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..426
                     /product="MFS transporter"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=46706
     Region          11..411
                     /region_name="MFS_ExuT_GudP_like"
                     /note="Hexuronate transporter, Glucarate transporter, and
                     similar transporters of the Major Facilitator Superfamily;
                     cd17319"
                     /db_xref="CDD:340877"
     Site            order(25..26,29..30,33,66,116..117,119..121,124,144,
                     147..148,151,240,243..244,247..249,252,281,285,337..338,
                     342,346,362,365..366,369..370,373)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340877"
ORIGIN      
        1 mnsstnatkr wwyimpivfi tyslayldra nfsfasaagi tedlgitkgi ssllgalffl
       61 gyfffqipga iyaerrsvrk lificlilwg gcasltgivh nipalaairf ilgvveaavm
      121 pamliyisnw ftksersran tflilgnpvt vlwmsvvsgy liqafgwrem fiiegvpavi
      181 wafcwwvlvk dkpsqvswla esekaalqeq ldreqqgika vrnygeafrs rnvillcaqy
      241 fawsigvygf vlwlpsiirs ggenmgmvev gwlssvpyla atiamivvsw asdklqnrkl
      301 fvwpllligg lafigswavg anhfwvsytl lvvagaamya pygpffaiip emlprnvagg
      361 amalinsmga lgsfcgswfv gylngatgsp aasyifmgva lfasvwltli vkpannqnlp
      421 lgahha