MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002921338             440 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_002921338
VERSION     WP_002921338.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 440)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 440)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 440)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024289
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..440
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=46895
     Region          22..417
                     /region_name="MFS_ShiA_like"
                     /note="Shikimate transporter and similar proteins of the
                     Major Facilitator Superfamily; cd17369"
                     /db_xref="CDD:340927"
     Site            order(34..35,38..39,42,81,139..140,142..144,147,167,
                     170..171,174,257,260..261,264..266,269,301,305,358..359,
                     363,367,383,386..387,390..391,394)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340927"
ORIGIN      
        1 mqatattlen tqetapvnsr nkvvvaslig taieffdfyi yataavivfp hiffpqgdaa
       61 aatlqslatf aiafvarpig salfghfgdr vgrkvtlvas lltmgistvv igllpgyeii
      121 givapmllal arfgqglglg gewggaalla tenaparkra lygsfpqlga pigfffangt
      181 flllswlltd qqfmewgwrv pfifsavlvi iglyvrvslh etpvfakvaa akkqvkiplg
      241 tlltkhvrvt vlgtfimlat ytlfyimtvy smtfstgaap nglglprnev lwmlmmavig
      301 fgvmvpvagl ladafgrrks miiittmiil falfafkpll gsgnpllvfa flllglslmg
      361 ltfgpmgall pelfptevry tgasfsynvs silgasvapy iaawlqgnyg laavgtylaa
      421 maaltliall lthetrhqsl