MULTISPECIES: type II toxin-antitoxin system Phd/YefM family

LOCUS       WP_002920802              73 aa            linear   BCT 16-DEC-2024
            antitoxin [Gammaproteobacteria].
ACCESSION   WP_002920802
VERSION     WP_002920802.1
KEYWORDS    RefSeq.
SOURCE      Gammaproteobacteria
  ORGANISM  Gammaproteobacteria
            Bacteria; Pseudomonadati; Pseudomonadota.
REFERENCE   1  (residues 1 to 73)
  AUTHORS   Garcia-Pino,A., De Gieter,S., Talavera,A., De Greve,H.,
            Efremov,R.G. and Loris,R.
  TITLE     An intrinsically disordered entropic switch determines allostery in
            Phd-Doc regulation
  JOURNAL   Nat Chem Biol 12 (7), 490-496 (2016)
   PUBMED   27159580
REFERENCE   2  (residues 1 to 73)
  AUTHORS   Garcia-Pino,A., Christensen-Dalsgaard,M., Wyns,L., Yarmolinsky,M.,
            Magnuson,R.D., Gerdes,K. and Loris,R.
  TITLE     Doc of prophage P1 is inhibited by its antitoxin partner Phd
            through fold complementation
  JOURNAL   J Biol Chem 283 (45), 30821-30827 (2008)
   PUBMED   18757857
REFERENCE   3  (residues 1 to 73)
  AUTHORS   Magnuson,R. and Yarmolinsky,M.B.
  TITLE     Corepression of the P1 addiction operon by Phd and Doc
  JOURNAL   J Bacteriol 180 (23), 6342-6351 (1998)
   PUBMED   9829946
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10005482
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..73
                     /organism="Gammaproteobacteria"
                     /db_xref="taxon:1236"
     Protein         1..73
                     /product="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
                     /GO_component="GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0097351 - toxin sequestering activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045927 - positive regulation of growth
                     [Evidence IEA]"
                     /calculated_mol_wt=8050
     Region          1..>48
                     /region_name="StbD"
                     /note="Antitoxin component YafN of the YafNO
                     toxin-antitoxin module, PHD/YefM family [Defense
                     mechanisms]; COG2161"
                     /db_xref="CDD:441764"
ORIGIN      
        1 mrtvnysear qnladvlesa vtgvpvtitr rghksaviis aeeferyqta rmddefaaim
       61 avhgdeirel adk