MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002918453             427 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_002918453
VERSION     WP_002918453.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 427)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 427)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 427)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022908
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..427
                     /product="MFS transporter"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=46263
     Region          6..414
                     /region_name="MFS_ExuT_GudP_like"
                     /note="Hexuronate transporter, Glucarate transporter, and
                     similar transporters of the Major Facilitator Superfamily;
                     cd17319"
                     /db_xref="CDD:340877"
     Site            order(20..21,24..25,28,60,110..111,113..115,118,138,
                     141..142,145,238,241..242,245..247,250,278,282,340..341,
                     345,349,365,368..369,372..373,376)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340877"
ORIGIN      
        1 mgknirwiiv lllflvymin yldrvalsit vpmiekdlal naeqfgiifg sfffgyavfn
       61 figglavdkf gatlvmglav glwslfcglt avatgfysml vlrvlfgmae gpicasankm
      121 ingwfpkkqa atavgflsag splggavagp ivgylalafg wrpafmiifa igivwmiawf
      181 fiaanspekh kkvsqeelkl inkmkeeeva letienqtah slgyylkqpi ilvtafaffc
      241 ynyilfffls wfpsylvqqh hldikqmslt tmipwivgfv glalggyisd kifkltgrll
      301 lsrkivlvvc llmaaicvgl agtvssvvpa vllmsvsiff lyvtgaiywa iiqdvvhksr
      361 vggasgfihl igsvsgivgp ivtgyivqst gkfdsafvla gtiaalgall vlfviktprv
      421 tmkasqa