MULTISPECIES: NADP(H)-dependent aldo-keto reductase [Klebsiella].

LOCUS       WP_002915975             346 aa            linear   BCT 20-NOV-2023
ACCESSION   WP_002915975
VERSION     WP_002915975.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 346)
  AUTHORS   Obmolova,G., Teplyakov,A., Khil,P.P., Howard,A.J.,
            Camerini-Otero,R.D. and Gilliland,G.L.
  TITLE     Crystal structure of the Escherichia coli Tas protein, an
            NADP(H)-dependent aldo-keto reductase
  JOURNAL   Proteins 53 (2), 323-325 (2003)
   PUBMED   14517983
REFERENCE   2  (residues 1 to 346)
  AUTHORS   Johnson,J.M. 3rd, Ding,W., Henkhaus,J. and Fix,D.
  TITLE     Identification of a mutation causing increased expression of the
            tas gene in Escherichia coli FX-11
  JOURNAL   Mutat. Res. 479 (1-2), 121-130 (2001)
   PUBMED   11470487
REFERENCE   3  (residues 1 to 346)
  AUTHORS   Timms,A.R. and Bridges,B.A.
  TITLE     Reversion of the tyrosine ochre strain Escherichia coli WU3610
            under starvation conditions depends on a new gene tas
  JOURNAL   Genetics 148 (4), 1627-1635 (1998)
   PUBMED   9560382
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF007912.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK10625
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..346
                     /product="NADP(H)-dependent aldo-keto reductase"
                     /GO_function="GO:0047834 - D-threo-aldose 1-dehydrogenase
                     activity [Evidence IEA]"
                     /calculated_mol_wt=38366
     Region          1..346
                     /region_name="tas"
                     /note="putative aldo-keto reductase; Provisional;
                     PRK10625"
                     /db_xref="CDD:236727"
     Site            order(19..21,26,48,53,87,132,179..180,205,233..239,242,
                     244,253..255,289,306..310,314,318)
                     /site_type="active"
                     /db_xref="CDD:381320"
     Site            order(48,53,87,132)
                     /site_type="active"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381320"
ORIGIN      
        1 mqyhriphss leistlglgt mtfgeqnsea dahqqldyav anginlidva emypvpprpe
       61 tqgltetyvg nwlakrgnre klvlaskvsg parnndssir pnhvldrkni realhaslkr
      121 lqtdyldlyq vhwpqrptnc fgklgytwad aapavtlldt lealtefqra gkiryigvsn
      181 etafgvmryl hladkhdlpr ivtiqnpysl lnrsfevgla evsqfegvel laysclafgt
      241 ltgkylngak pagarntlfs rftrysseqs qkavaayvdi akrhgldpaq malafvrrqp
      301 fvastllgat tmtqlqanve slqlelseev laeieavhqv ytypap