MULTISPECIES: NADPH-dependent 7-cyano-7-deazaguanine reductase QueF

LOCUS       WP_002915255             281 aa            linear   BCT 28-FEB-2022
            [Klebsiella].
ACCESSION   WP_002915255
VERSION     WP_002915255.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 281)
  AUTHORS   Kim,Y., Zhou,M., Moy,S., Morales,J., Cunningham,M.A. and
            Joachimiak,A.
  TITLE     High-resolution structure of the nitrile reductase QueF combined
            with molecular simulations provide insight into enzyme mechanism
  JOURNAL   J Mol Biol 404 (1), 127-137 (2010)
   PUBMED   20875425
REFERENCE   2  (residues 1 to 281)
  AUTHORS   Van Lanen,S.G., Reader,J.S., Swairjo,M.A., de Crecy-Lagard,V.,
            Lee,B. and Iwata-Reuyl,D.
  TITLE     From cyclohydrolase to oxidoreductase: discovery of nitrile
            reductase activity in a common fold
  JOURNAL   Proc Natl Acad Sci U S A 102 (12), 4264-4269 (2005)
   PUBMED   15767583
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR03138.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..281
                     /gene="queF"
     Protein         1..281
                     /product="NADPH-dependent 7-cyano-7-deazaguanine reductase
                     QueF"
                     /EC_number="1.7.1.13"
                     /GO_function="GO:0033739 - preQ1 synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0043867 - 7-cyano-7-deazaguanine
                     tRNA-ribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /note="Catalyzes the NADPH-dependent reduction of
                     7-cyano-7-deazaguanine (preQ0) to
                     7-aminomethyl-7-deazaguanine (preQ1) in queuosine
                     biosynthesis"
                     /calculated_mol_wt=31736
     Region          9..281
                     /region_name="queF"
                     /note="7-cyano-7-deazaguanine reductase; Provisional;
                     PRK11792"
                     /db_xref="CDD:236986"
ORIGIN      
        1 mssydnkqal agltlgkstd yrdtydasll qgvprslnrd plglhadnlp fhgadiwtly
       61 elswlngkgl pqvavghvel pdtslnlves ksfklylnsf nqtrfaswqd vaetltrdls
      121 acaqgkvkvs lyrldelegq piarlhgtci ddqdieidny qfsadylqga asgkiveetl
      181 vshllksncl ithqpdwgsv qiqyrgakid reqllrylvs frhhnefheq cverifndil
      241 rfcqpeslsv yarytrrggl dinpwrsngd fspatgrlar q