MULTISPECIES: glutamate--cysteine ligase [Klebsiella].

LOCUS       WP_002914353             518 aa            linear   BCT 25-NOV-2024
ACCESSION   WP_002914353
VERSION     WP_002914353.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 518)
  AUTHORS   Wongsaroj,L., Saninjuk,K., Romsang,A., Duang-Nkern,J.,
            Trinachartvanit,W., Vattanaviboon,P. and Mongkolsuk,S.
  TITLE     Pseudomonas aeruginosa glutathione biosynthesis genes play multiple
            roles in stress protection, bacterial virulence and biofilm
            formation
  JOURNAL   PLoS One 13 (10), e0205815 (2018)
   PUBMED   30325949
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 518)
  AUTHORS   Hibi,T., Nii,H., Nakatsu,T., Kimura,A., Kato,H., Hiratake,J. and
            Oda,J.
  TITLE     Crystal structure of gamma-glutamylcysteine synthetase: insights
            into the mechanism of catalysis by a key enzyme for glutathione
            homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 101 (42), 15052-15057 (2004)
   PUBMED   15477603
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01434.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..518
                     /gene="gshA"
     Protein         1..518
                     /product="glutamate--cysteine ligase"
                     /EC_number="6.3.2.2"
                     /GO_function="GO:0004357 - glutamate-cysteine ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006750 - glutathione biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=57970
     Region          6..517
                     /region_name="glu_cys_ligase"
                     /note="glutamate--cysteine ligase; TIGR01434"
                     /db_xref="CDD:213621"
ORIGIN      
        1 mipdvsqala wlekhpqalq giqrgleret lrvnadgtla ttghppalgs althkwittd
       61 faeallefit pvdgdiehml tfmrdvhryt arqlgdermw plsmpcyiap gqdielaqyg
      121 tsnvgrlktl yreglknryg almqtisgvh ynfslpmafw qakcgvedae sgkeaisagy
      181 frsirnyyrf gwvipylfga spaicssflq gkpttlpfee tgngmyylpy atslrlsdlg
      241 ytnksqsnlg itfndlheyv aglkraiktp seeyakiglq kdgkylqins nilqienely
      301 apirpkrvtr rgetpsdall rggieyievr sldinpfspi gvdaqqvrfl dlfmvwcala
      361 dapemssdel lctrtnwnrv ilegrkpglt lgigcesaqf plaqvgkdlf rdlrrvaqtl
      421 dsihggqayq qvcdellacf ddpeltfsar ilrsmieegi ggtgraladr yrtqlreepl
      481 eilseddfia erdasvarqk kveaedsepf eallarha