MULTISPECIES: translation elongation factor 4 [Klebsiella].

LOCUS       WP_002914069             599 aa            linear   BCT 20-NOV-2023
ACCESSION   WP_002914069
VERSION     WP_002914069.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 599)
  AUTHORS   Gibbs,M.R., Moon,K.M., Chen,M., Balakrishnan,R., Foster,L.J. and
            Fredrick,K.
  TITLE     Conserved GTPase LepA (Elongation Factor 4) functions in biogenesis
            of the 30S subunit of the 70S ribosome
  JOURNAL   Proc Natl Acad Sci U S A 114 (5), 980-985 (2017)
   PUBMED   28096346
REFERENCE   2  (residues 1 to 599)
  AUTHORS   Song,G. and Qin,Y.
  TITLE     EF4 reveals the energy barrier for tRNA back-translocation in the
            peptidyl transferase center
  JOURNAL   RNA Biol 13 (10), 934-939 (2016)
   PUBMED   27472653
REFERENCE   3  (residues 1 to 599)
  AUTHORS   Kumar,V., Ero,R., Ahmed,T., Goh,K.J., Zhan,Y., Bhushan,S. and
            Gao,Y.G.
  TITLE     Structure of the GTP Form of Elongation Factor 4 (EF4) Bound to the
            Ribosome
  JOURNAL   J Biol Chem 291 (25), 12943-12950 (2016)
   PUBMED   27137929
REFERENCE   4  (residues 1 to 599)
  AUTHORS   Liu,H., Chen,C., Zhang,H., Kaur,J., Goldman,Y.E. and Cooperman,B.S.
  TITLE     The conserved protein EF4 (LepA) modulates the elongation cycle of
            protein synthesis
  JOURNAL   Proc Natl Acad Sci U S A 108 (39), 16223-16228 (2011)
   PUBMED   21930951
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01393.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..599
                     /gene="lepA"
     Protein         1..599
                     /product="translation elongation factor 4"
                     /EC_number="3.6.5.n1"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /calculated_mol_wt=66304
     Region          1..595
                     /region_name="LepA"
                     /note="Translation elongation factor EF-4, membrane-bound
                     GTPase [Translation, ribosomal structure and biogenesis];
                     COG0481"
                     /db_xref="CDD:440249"
ORIGIN      
        1 mknirnfsii ahidhgkstl sdriiqicgg lsdremeaqv ldsmdlerer gitikaqsvt
       61 ldykasdget yqlnfidtpg hvdfsyevsr slaacegall vvdagqgvea qtlancytam
      121 emdlevvpvl nkidlpaadp ervadeiedi vgidahdavr csaktgvgvt dvlerlvrdi
      181 pppegdpdap lqaliidswf dnylgvvslv rikngtmrkg dkikvmstgq vynadrlgif
      241 tpkqvdrtel kcgevgwlvc aikdilgapv gdtltaarnp adkalpgfkk vkpqvyaglf
      301 pvssddyeaf rdalgklsln daslfyepes stalgfgfrc gflgllhmei iqerlereyd
      361 ldlittaptv vyevettske viyvdspskl pplnniqelr epiaechmll pqeflgnvit
      421 lcvekrgvqt nmvyhgkqva ltyeipmaev vldffdrlks tsrgyasldy nfkrfqasnm
      481 vrvdvlinge rvdalalith ndnapyrgre lvekmkdlip rqqfdiaiqa aignhiiars
      541 tvkqlrknvl akcyggdvsr kkkllqkqke gkkrmkqvgn velpqeafla ilhvgkdgk