MULTISPECIES: serine hydroxymethyltransferase [Klebsiella].

LOCUS       WP_002914027             417 aa            linear   BCT 20-NOV-2023
ACCESSION   WP_002914027
VERSION     WP_002914027.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 417)
  AUTHORS   Appaji Rao,N., Ambili,M., Jala,V.R., Subramanya,H.S. and
            Savithri,H.S.
  TITLE     Structure-function relationship in serine hydroxymethyltransferase
  JOURNAL   Biochim Biophys Acta 1647 (1-2), 24-29 (2003)
   PUBMED   12686103
REFERENCE   2  (residues 1 to 417)
  AUTHORS   Stover,P. and Schirch,V.
  TITLE     Serine hydroxymethyltransferase catalyzes the hydrolysis of
            5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate
  JOURNAL   J Biol Chem 265 (24), 14227-14233 (1990)
   PUBMED   2201683
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10011056
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..417
                     /gene="glyA"
     Protein         1..417
                     /product="serine hydroxymethyltransferase"
                     /EC_number="2.1.2.1"
                     /GO_function="GO:0004372 - glycine
                     hydroxymethyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0070905 - serine binding [Evidence IEA]"
                     /GO_process="GO:0019264 - glycine biosynthetic process
                     from serine [Evidence IEA]"
                     /calculated_mol_wt=45309
     Region          6..417
                     /region_name="glyA"
                     /note="serine hydroxymethyltransferase; Reviewed;
                     PRK00011"
                     /db_xref="CDD:234571"
     Site            order(12,14,21..22,31,36,54,72..73,81,96,103,138..139,265,
                     283)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:99733"
     Site            order(35,55,65,98..99,126,175,200,203,228..229,235,363)
                     /site_type="other"
                     /note="glycine-pyridoxal phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:99733"
     Site            order(35,126,229,363)
                     /site_type="active"
                     /db_xref="CDD:99733"
     Site            order(57,64,121,125,127,257,347)
                     /site_type="other"
                     /note="folate binding site [chemical binding]"
                     /db_xref="CDD:99733"
ORIGIN      
        1 mlkremniad ydaelwqame qekvrqeehi eliasenyts prvmqaqgsq ltnkyaegyp
       61 gkryyggcey vdvveqlaid rakelfgady anvqphsgsq anfavytall qpgdtvlgmn
      121 laqgghlthg spvnfsgkly niipygides gkidyddmak qaqehkpkmi iggfsaysgi
      181 vdwakmreia dsigaylfvd mahvagliaa gvypnpvpha hvvtttthkt lagprgglil
      241 akggseelyk klnsavfpsa qggplmhvia akavalkeam epefkvyqqq vaknakamve
      301 vflnrgykvv sggtenhlfl ldlvdknltg keadaalgra nitvnknsvp ndpkspfvts
      361 girigspavt rrgfkeaevk elagwmcdvl dninddavie rvkgkvldic arfpvya