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LOCUS WP_002914022 398 aa linear BCT 21-JAN-2025 ACCESSION WP_002914022 VERSION WP_002914022.1 KEYWORDS RefSeq. SOURCE Klebsiella ORGANISM Klebsiella Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group. REFERENCE 1 (residues 1 to 398) AUTHORS Conejo,M.S., Thompson,S.M. and Miller,B.G. TITLE Evolutionary bases of carbohydrate recognition and substrate discrimination in the ROK protein family JOURNAL J Mol Evol 70 (6), 545-556 (2010) PUBMED 20512568 REFERENCE 2 (residues 1 to 398) AUTHORS Larion,M., Moore,L.B., Thompson,S.M. and Miller,B.G. TITLE Divergent evolution of function in the ROK sugar kinase superfamily: role of enzyme loops in substrate specificity JOURNAL Biochemistry 46 (47), 13564-13572 (2007) PUBMED 17979299 REFERENCE 3 (residues 1 to 398) AUTHORS Aravind,L., Anantharaman,V., Balaji,S., Babu,M.M. and Iyer,L.M. TITLE The many faces of the helix-turn-helix domain: transcription regulation and beyond JOURNAL FEMS Microbiol Rev 29 (2), 231-262 (2005) PUBMED 15808743 REFERENCE 4 (residues 1 to 398) AUTHORS Wintjens,R. and Rooman,M. TITLE Structural classification of HTH DNA-binding domains and protein-DNA interaction modes JOURNAL J Mol Biol 262 (2), 294-313 (1996) PUBMED 8831795 REFERENCE 5 (residues 1 to 398) AUTHORS Hurley,J.H. TITLE The sugar kinase/heat shock protein 70/actin superfamily: implications of conserved structure for mechanism JOURNAL Annu Rev Biophys Biomol Struct 25, 137-162 (1996) PUBMED 8800467 REFERENCE 6 (residues 1 to 398) AUTHORS Kabsch,W. and Holmes,K.C. TITLE The actin fold JOURNAL FASEB J 9 (2), 167-174 (1995) PUBMED 7781919 REFERENCE 7 (residues 1 to 398) AUTHORS Titgemeyer,F., Reizer,J., Reizer,A. and Saier,M.H. Jr. TITLE Evolutionary relationships between sugar kinases and transcriptional repressors in bacteria JOURNAL Microbiology (Reading) 140 (Pt 9), 2349-2354 (1994) PUBMED 7952186 REFERENCE 8 (residues 1 to 398) AUTHORS Brennan,R.G. and Matthews,B.W. TITLE The helix-turn-helix DNA binding motif JOURNAL J Biol Chem 264 (4), 1903-1906 (1989) PUBMED 2644244 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 20682457 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..398 /organism="Klebsiella" /db_xref="taxon:570" Protein 1..398 /product="ROK family transcriptional regulator" /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /calculated_mol_wt=44357 Region 20..58 /region_name="HTH_24" /note="Winged helix-turn-helix DNA-binding; pfam13412" /db_xref="CDD:404317" Region 82..391 /region_name="ASKHA_ATPase-like" /note="ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; cl49607" /db_xref="CDD:483947" ORIGIN 1 mqrtgfdnar vrqanksifl shlwrekqls ksqlsqltgl sipavsnila ellsegligh 61 stehlskrgv nsgsyqipeh gawtlcmnit ptsieyqlad arllavdghq hlpvnaptpq 121 alleaivecw rhihrrypqh sinlalgvhg qvdpitgvsq tmpqarwktp ieikylleer 181 lgvqvrvdnd cvmlalaekw qhqgtqqdfc vinvdygigs sfvindhiyr gslygsgqig 241 htivnpdgka cdcgrygcle tvaslsalkk qarmwlktqp eatlspeqlt taslieawke 301 gdvqirawvd naanaiglsl ynflnilnin qiwlygrsca fgeqwlesiv kqtgfnpfdh 361 rdtprahatq igfgqltraq qlmgigylyv eeqlqtlv