MULTISPECIES: sugar porter family MFS transporter [Klebsiella].

LOCUS       WP_002914018             478 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_002914018
VERSION     WP_002914018.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 478)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 478)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 478)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024203
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..478
                     /product="sugar porter family MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=51465
     Region          15..449
                     /region_name="MFS_XylE_like"
                     /note="D-xylose-proton symporter and similar transporters
                     of the Major Facilitator Superfamily; cd17359"
                     /db_xref="CDD:340917"
     Site            order(27,146,149,153,278..279,283..284,287..288,373,
                     377..378,382,405..406,409)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:340917"
ORIGIN      
        1 mnnaqthlkm gyvwticlva acggllfgyd wvviggakpf yeawfsitdp aqsgwamssa
       61 llgcifgali sgwcadklgr klplilsavl fsasawgtav ashfdmfvvy rivggvgigl
      121 asalsplyia evspaekrgr fvavnqltiv igvlaaqlin lmiaepvepg atqqmivdsw
      181 ngqmgwrwmf gaelvpalaf lvlmffvpes prwlmkagkp eraraaleri gsadyadril
      241 reiahtlekd nnkvsygall apqvkpivii gmvlaifqqw cginvifnya qeifasagfd
      301 instlksiva tgvvnlvfti aalplvdkig rrklmllgas gltliyvlia gayamgimgw
      361 pvlllvlaai aiyaltlapv twvllaeifp nrvrglamsl gtlalwiacf lltytfplln
      421 aglgaagsfl lygvicaagy lyilrnvpet kgitlealee qlaqrhtgvn aakqeqmr