MULTISPECIES: cysteine desulfurase [Klebsiella].

LOCUS       WP_002913992             404 aa            linear   BCT 20-NOV-2023
ACCESSION   WP_002913992
VERSION     WP_002913992.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 404)
  AUTHORS   Kim,J.H., Tonelli,M. and Markley,J.L.
  TITLE     Disordered form of the scaffold protein IscU is the substrate for
            iron-sulfur cluster assembly on cysteine desulfurase
  JOURNAL   Proc Natl Acad Sci U S A 109 (2), 454-459 (2012)
   PUBMED   22203963
REFERENCE   2  (residues 1 to 404)
  AUTHORS   Cupp-Vickery,J.R., Urbina,H. and Vickery,L.E.
  TITLE     Crystal structure of IscS, a cysteine desulfurase from Escherichia
            coli
  JOURNAL   J Mol Biol 330 (5), 1049-1059 (2003)
   PUBMED   12860127
REFERENCE   3  (residues 1 to 404)
  AUTHORS   Urbina,H.D., Silberg,J.J., Hoff,K.G. and Vickery,L.E.
  TITLE     Transfer of sulfur from IscS to IscU during Fe/S cluster assembly
  JOURNAL   J Biol Chem 276 (48), 44521-44526 (2001)
   PUBMED   11577100
REFERENCE   4  (residues 1 to 404)
  AUTHORS   Schwartz,C.J., Djaman,O., Imlay,J.A. and Kiley,P.J.
  TITLE     The cysteine desulfurase, IscS, has a major role in in vivo Fe-S
            cluster formation in Escherichia coli
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 9009-9014 (2000)
   PUBMED   10908675
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR010983
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..404
                     /gene="iscS"
     Protein         1..404
                     /product="cysteine desulfurase"
                     /EC_number="2.8.1.7"
                     /calculated_mol_wt=44926
     Region          1..404
                     /region_name="PRK14012"
                     /note="IscS subfamily cysteine desulfurase"
                     /db_xref="CDD:184450"
     Site            order(75..76,79,152,180,183,203,206)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:99746"
     Site            206
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99746"
ORIGIN      
        1 mklpiyldys attpvdprva ekmmqfltmd gtfgnpasrs hrfgwqaeea vdiarnqiae
       61 lvgadpreiv ftsgatesdn laikgaanfy qkkgkhiits ktehkavldt crqleregfe
      121 vtylapqsng iidlkeleaa mrddtilvsi mhvnneigvv qdiatigemc rargiiyhvd
      181 atqsvgklpi dlsqlkvdlm sfsghkiygp kgigalyvrr kpririeaqi hggghergmr
      241 sgtlpvhqiv gmgeayriak eemesemarl rtlrnrlwng vkdmeevyln gdleqgapni
      301 lnvsfnyveg eslimalkdl avssgsacts aslepsyvlr algmtdelah ssirfslgrf
      361 tteeeidyai dlirksigrl relsplwemf kqgvdlnsie wshh