MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002913847             410 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_002913847
VERSION     WP_002913847.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 410)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 410)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 410)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024122
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..410
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=43363
     Region          7..379
                     /region_name="MFS_YcxA_like"
                     /note="MFS-type transporter YcxA and similar proteins of
                     the Major Facilitator Superfamily of transporters;
                     cd17355"
                     /db_xref="CDD:340913"
     Site            order(18..19,22..23,26,62,109..110,112..114,117,140,
                     143..144,147,213,216..217,220..222,225,250,254,305..306,
                     310,314,330,333..334,337..338,341)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340913"
ORIGIN      
        1 meinaiprrl aftaggqqli nwgisfympg tfagaiaadk gwslpqiylg ltlamlmmaa
       61 vspfvarlla rfggrlvvts gtlliaasca mmawrpslag wygawlltgi gmrlslydal
      121 faavvnlygq qarktishit lagglasalf wplgeallti mpwqnalriy alfgllsawl
      181 syqlprqrls saakspaspa taegdrrnga ryaifialit fisngtsthl pefishfglp
      241 vavgmlwgfg qtgarlgevl agprvtsltl trftalampl cfllglsstt fagcaagfvl
      301 gygainglvt ivkatlplal fsaesyasrt glllipgqlm aavspfayaw lnhrlgiigg
      361 mwvstgltli vaglalamvr eagkaqdern veypaaavdq piaknnlaee