MULTISPECIES: bifunctional hydroxymethylpyrimidine

LOCUS       WP_002912707             266 aa            linear   BCT 20-NOV-2023
            kinase/phosphomethylpyrimidine kinase [Klebsiella].
ACCESSION   WP_002912707
VERSION     WP_002912707.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 266)
  AUTHORS   Mizote,T., Tsuda,M., Smith,D.D., Nakayama,H. and Nakazawa,T.
  TITLE     Cloning and characterization of the thiD/J gene of Escherichia coli
            encoding a thiamin-synthesizing bifunctional enzyme,
            hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
  JOURNAL   Microbiology (Reading, Engl.) 145 (Pt 2), 495-501 (1999)
   PUBMED   10075431
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00097.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..266
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..266
                     /gene="thiD"
     Protein         1..266
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /GO_function="GO:0008902 - hydroxymethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008972 - phosphomethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=28246
     Region          1..266
                     /region_name="PRK06427"
                     /note="bifunctional hydroxy-methylpyrimidine kinase/
                     hydroxy-phosphomethylpyrimidine kinase; Reviewed"
                     /db_xref="CDD:180561"
     Site            order(5,12,14..15,17,21,24..25,28,31..36,38,41..45,50..51,
                     53,55..56,59,62,66..67)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238574"
     Site            order(11,23,44,80,213)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238574"
     Site            order(105,142,176,210,212)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:238574"
ORIGIN      
        1 mkrinaltia gtdpsggagi qadlktfsal gaygcsaita lvaqntrgvq svyriepdfv
       61 aaqldsvfsd vridttkigm laetdiveav aerlaryrva nvvldtvmla ksgdpllsas
      121 avetlrqrll pqvslitpnl peaaalldap harneremle qgrallalgc gavlmkgghl
      181 ddaespdwlf tregeqrfta prvqtknthg tgctlsaala alrprhadwa atvieakawl
      241 saalaqadsl evghgigpvh hfhaww