MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002911499             527 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_002911499
VERSION     WP_002911499.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 527)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 527)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 527)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   4  (residues 1 to 527)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023745
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..527
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=58079
     Region          11..451
                     /region_name="MFS_MelB_like"
                     /note="Salmonella enterica Na+/melibiose symporter MelB
                     and similar transporters of the Major Facilitator
                     Superfamily; cd17332"
                     /db_xref="CDD:340890"
     Site            order(21..22,25..26,29,62,122..123,125..127,130,151,
                     154..155,158,253,256..257,260..262,265,294,298,352..353,
                     357,361,384,387..388,391..392,395)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340890"
ORIGIN      
        1 mktrkiglan ylaygagdfl gagttaltaa wllyfyttfc gltpieatli faaarvldav
       61 vsplmgfltd nfgttwlgkr fgrrkffill gipcvfsysa mwvgemgfwy ylatyllfdm
      121 vytmilvpye tlvpemtddf kqktkfsgar ismaqmsail asflpgills wlgkdnassf
      181 fyaslvfsvl cavmltlvwc ftwerpreaw seaalraeae kqnltlaqsl nrlvielsst
      241 lrikifrqhl gmylggyiaq dvfnavftyy vvfvlmqeaa vasnllgtma ifqfiaviam
      301 iplcirfgpa psyrmvvvlf glsslsyall yyaglsdvys llllisavag lgrgginyvp
      361 wntytyiadv deaitgqrre gifagimtlt rkasqagavm lvgiimqlsg fvsgqkiqpe
      421 gvshtillil svgtlvvlac gflvslrfkl nlhthsvlrs etlrmrelgy aqseqtsaeh
      481 ravvellagm pydclwgnnn igylnrhkpa apalikggal nstytrg