MULTISPECIES: GGDEF domain-containing protein [Klebsiella].

LOCUS       WP_002904600             474 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_002904600
VERSION     WP_002904600.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 474)
  AUTHORS   Cotter,P.A. and Stibitz,S.
  TITLE     c-di-GMP-mediated regulation of virulence and biofilm formation
  JOURNAL   Curr Opin Microbiol 10 (1), 17-23 (2007)
   PUBMED   17208514
REFERENCE   2  (residues 1 to 474)
  AUTHORS   Simm,R., Fetherston,J.D., Kader,A., Romling,U. and Perry,R.D.
  TITLE     Phenotypic convergence mediated by GGDEF-domain-containing proteins
  JOURNAL   J Bacteriol 187 (19), 6816-6823 (2005)
   PUBMED   16166544
  REMARK    Erratum:[J Bacteriol. 2006 Mar;188(5):2024]
REFERENCE   3  (residues 1 to 474)
  AUTHORS   Chan,C., Paul,R., Samoray,D., Amiot,N.C., Giese,B., Jenal,U. and
            Schirmer,T.
  TITLE     Structural basis of activity and allosteric control of diguanylate
            cyclase
  JOURNAL   Proc Natl Acad Sci U S A 101 (49), 17084-17089 (2004)
   PUBMED   15569936
REFERENCE   4  (residues 1 to 474)
  AUTHORS   Pei,J. and Grishin,N.V.
  TITLE     GGDEF domain is homologous to adenylyl cyclase
  JOURNAL   Proteins 42 (2), 210-216 (2001)
   PUBMED   11119645
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10112692
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..474
                     /product="GGDEF domain-containing protein"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0052621 - diguanylate cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /calculated_mol_wt=51800
     Region          39..>293
                     /region_name="PRK09776"
                     /note="putative diguanylate cyclase; Provisional"
                     /db_xref="CDD:182070"
     Region          196..466
                     /region_name="GGDEF"
                     /note="GGDEF domain, diguanylate cyclase (c-di-GMP
                     synthetase) or its enzymatically inactive variants [Signal
                     transduction mechanisms]; COG2199"
                     /db_xref="CDD:441801"
ORIGIN      
        1 msslsirsft lfreeqpvrd alvlftltll lhflgamlrl vqelsffwpl navmagifar
       61 yvwlnrsyfy avcfaamlvy dgltsrwgmg fasllinfsn ivfivtlaql vlwdkrrads
      121 mpgpinalnl fcfcllaall caavgalgsv dveratfvpq ladwfseqfs tavlilpfil
      181 tltlpsalsg frfrqllpvl alvlsialgl avggagsitf plpaliwcav ryplpltcll
      241 tfltgigeil lvanslihfs pdarmqpwql fstrlgiaam lispvivass veaintlvkq
      301 lalradfdfq trvysrsgls ealkrqtlpa dklltvmvld idgfkrvnda lgheggdcvl
      361 tqfaqqvrql vgeqgmvari ggeefavaav vdsaqqgyll aekirhgves qpfglgqnpi
      421 hltislglet revgharite lfnqlllaad demvkakqsg rnqicmptlt esap