MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002903724             427 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_002903724
VERSION     WP_002903724.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 427)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 427)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 427)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022908
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..427
                     /product="MFS transporter"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=45929
     Region          25..421
                     /region_name="MFS_ExuT_GudP_like"
                     /note="Hexuronate transporter, Glucarate transporter, and
                     similar transporters of the Major Facilitator Superfamily;
                     cd17319"
                     /db_xref="CDD:340877"
     Site            order(35..36,39..40,43,75,125..126,128..130,133,153,
                     156..157,160,245,248..249,252..254,257,285,289,347..348,
                     352,356,372,375..376,379..380,383)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340877"
ORIGIN      
        1 maietlaart gatplrirrv qkitltllfi agivnfldrs slsvageair adlglsatef
       61 gvllsafsls ygfaqlpsgi lldrlgpriv lgaglifwsa mqaltgmvns fshfillrig
      121 lgigeapfmp agvksindwy aqrergtavg ifnsstvlgq aiappalvim qlawgwrtmf
      181 vviglagivv glcwyvgyrn rrqftlqeee qqylaseeaa rpalkfsewl alfkrrttwg
      241 milgfsgvny tgwlyiawlp gylqaqqgls lartgwvaai pflaaavgmw vnglvvdala
      301 rrgydqaktr ktaiviglvl salgtllvvq sstpaqavaf ismalfcvhf agtsawglvq
      361 vmvaehkvas vaaiqnfgsf vfasfapivt gwvvdtthsf nlalviaagv tfagalcyff
      421 ivktrid