MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002903698             416 aa            linear   BCT 22-JUL-2024
ACCESSION   WP_002903698
VERSION     WP_002903698.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 416)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 416)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023516
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..416
                     /product="MFS transporter"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=44544
     Region          38..397
                     /region_name="MFS_NepI_like"
                     /note="Purine ribonucleoside efflux pump NepI and similar
                     transporters of the Major Facilitator Superfamily;
                     cd17324"
                     /db_xref="CDD:340882"
     Site            order(48..49,52..53,56,88,138..139,141..143,146,166,
                     169..170,173,247,250..251,254..256,259,287,291,339..340,
                     344,348,363,366..367,370..371,374)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340882"
ORIGIN      
        1 msrtttvdtv pagevsvaga srpdpfikrg tpqfmrvtla lfsaglatfa llycvqpilp
       61 vlsnefgvsp asssislsis tamlavgllf tgplsdaigr kpvmvtalll aaccsllstm
      121 mtswhgilim raliglslsg vaavgmtyls eeihpsfvaf smglyisgns iggmsgrllt
      181 gvftdffgwr valaaisgfa laaaimfwri lpesrhfrpt slrpktllin frlhwrdrgl
      241 pllfiegfll mgafvtlfny igyrlmmspw slsqavvgll svayltgtws spkagamtvr
      301 fgrgpvmlgf tavmlcglll tlfsslwlif igmllfsagf faahsvassw igprarrarg
      361 qasslylfsy ylgsslagtl ggvfwhhygw ngvggfiall llaalltgtc lhqrlk