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MULTISPECIES: CorA family divalent cation transporter [Klebsiella].


LOCUS       WP_002903242             342 aa            linear   BCT 02-MAR-2025
ACCESSION   WP_002903242
VERSION     WP_002903242.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 342)
  AUTHORS   Nordin,N., Guskov,A., Phua,T., Sahaf,N., Xia,Y., Lu,S., Eshaghi,H.
            and Eshaghi,S.
  TITLE     Exploring the structure and function of Thermotoga maritima CorA
            reveals the mechanism of gating and ion selectivity in Co2+/Mg2+
            transport
  JOURNAL   Biochem J 451 (3), 365-374 (2013)
   PUBMED   23425532
  REMARK    Erratum:[Biochem J. 2013 Jun 1;452(2):367-8]
REFERENCE   2  (residues 1 to 342)
  AUTHORS   Niegowski,D. and Eshaghi,S.
  TITLE     The CorA family: structure and function revisited
  JOURNAL   Cell Mol Life Sci 64 (19-20), 2564-2574 (2007)
   PUBMED   17619822
REFERENCE   3  (residues 1 to 342)
  AUTHORS   Lunin,V.V., Dobrovetsky,E., Khutoreskaya,G., Zhang,R.,
            Joachimiak,A., Doyle,D.A., Bochkarev,A., Maguire,M.E., Edwards,A.M.
            and Koth,C.M.
  TITLE     Crystal structure of the CorA Mg2+ transporter
  JOURNAL   Nature 440 (7085), 833-837 (2006)
   PUBMED   16598263
REFERENCE   4  (residues 1 to 342)
  AUTHORS   Worlock,A.J. and Smith,R.L.
  TITLE     ZntB is a novel Zn2+ transporter in Salmonella enterica serovar
            Typhimurium
  JOURNAL   J Bacteriol 184 (16), 4369-4373 (2002)
   PUBMED   12142406
REFERENCE   5  (residues 1 to 342)
  AUTHORS   Smith,R.L., Szegedy,M.A., Kucharski,L.M., Walker,C., Wiet,R.M.,
            Redpath,A., Kaczmarek,M.T. and Maguire,M.E.
  TITLE     The CorA Mg2+ transport protein of Salmonella typhimurium.
            Mutagenesis of conserved residues in the third membrane domain
            identifies a Mg2+ pore
  JOURNAL   J Biol Chem 273 (44), 28663-28669 (1998)
   PUBMED   9786860
REFERENCE   6  (residues 1 to 342)
  AUTHORS   Kehres,D.G., Lawyer,C.H. and Maguire,M.E.
  TITLE     The CorA magnesium transporter gene family
  JOURNAL   Microb Comp Genomics 3 (3), 151-169 (1998)
   PUBMED   9775386
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF013694.6
            Evidence Source    :: EMBL-EBI
            Source Identifier  :: PF01544.23
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..342
                     /product="CorA family divalent cation transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=39098
     Region          54..341
                     /region_name="MIT_CorA-like"
                     /note="metal ion transporter CorA-like divalent cation
                     transporter superfamily; cl00459"
                     /db_xref="CDD:469776"
     Site            order(78,81..82,92,94,143,147,158,161,165,169,172..173,
                     176,179..180,182..183,186,198..199,201..202,205..206,
                     209..210,212..213,217,219..220,223..224,227..228,239..240,
                     242..243,246..247,249..250,253..254,256..257,259..261,
                     264..271,273..285,287..289,291..296,298..305,317..318,
                     321..322,334,337)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:213354"
ORIGIN      
        1 mnqdvtakml kpdfdsevsg lvhgylfheq rppqpiasge vcaryqalad dkafiwlhln
       61 lnhataekwl tshfpvadff feeirsgsht trierqgenl favlndvlfr pqdtsaetat
      121 lwlycsprlv vtarfkplrf iewmlprlqt lrvntstell aflleeqeev leqvvrqasr
      181 hvdlieerll snhvqrnrad larlrrmllr fqrllapepa amfrllnrpp awmdravvqa
      241 frqfteefsv vlndlsglie risllqeeig arqleqsnrt lytltvitvl alpinivagf
      301 fgmnvggipl asnhhgfill vvivavftlg agylafrrrd dl