MULTISPECIES: aldo/keto reductase [Klebsiella].

LOCUS       WP_002902972             332 aa            linear   BCT 19-MAR-2023
ACCESSION   WP_002902972
VERSION     WP_002902972.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 332)
  AUTHORS   Penning,T.M.
  TITLE     The aldo-keto reductases (AKRs): Overview
  JOURNAL   Chem Biol Interact 234, 236-246 (2015)
   PUBMED   25304492
REFERENCE   2  (residues 1 to 332)
  AUTHORS   Mindnich,R.D. and Penning,T.M.
  TITLE     Aldo-keto reductase (AKR) superfamily: genomics and annotation
  JOURNAL   Hum Genomics 3 (4), 362-370 (2009)
   PUBMED   19706366
REFERENCE   3  (residues 1 to 332)
  AUTHORS   Sanli,G., Dudley,J.I. and Blaber,M.
  TITLE     Structural biology of the aldo-keto reductase family of enzymes:
            catalysis and cofactor binding
  JOURNAL   Cell Biochem Biophys 38 (1), 79-101 (2003)
   PUBMED   12663943
REFERENCE   4  (residues 1 to 332)
  AUTHORS   Jez,J.M., Bennett,M.J., Schlegel,B.P., Lewis,M. and Penning,T.M.
  TITLE     Comparative anatomy of the aldo-keto reductase superfamily
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 625-636 (1997)
   PUBMED   9307009
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 14442355
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..332
                     /product="aldo/keto reductase"
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /calculated_mol_wt=36331
     Region          2..304
                     /region_name="AKR_AKR13A_13D"
                     /note="AKR13A and AKR13D families of aldo-keto reductase
                     (AKR); cd19076"
                     /db_xref="CDD:381302"
     Site            order(21,207..210,213,263,281..285,288,291..292)
                     /site_type="active"
                     /db_xref="CDD:381302"
     Site            order(51,56,81,128)
                     /site_type="active"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381302"
ORIGIN      
        1 mktrylgkek fqvsalglgc mgmsfaygga etsqaintih aamdmgvtfl dtaevygpfd
       61 nevlvgkaik gfrdkvqiat kfgfrilptg qglermagvd srpahiresv egslkrlnve
      121 tidllyqhrv dpavpveevv gtmadlvkeg kirhiglsev saqtlrrack vhpiaavqte
      181 yslwsrepea gilhtcrelg vgfvpysplg rgfltgtitd pgvlaaddfr rhlprfqaet
      241 mrknqlller lqqvatryda tlaqialawv mskgedivpi pgarkiahlr dnagaanitl
      301 aaediltieh iftadnvtgl rytqgdfdli ek