MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002901901             463 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_002901901
VERSION     WP_002901901.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 463)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 463)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 463)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022956
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..463
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48189
     Region          21..457
                     /region_name="MFS_MMR_MDR_like"
                     /note="Methylenomycin A resistance protein (also called
                     MMR peptide) and similar multidrug resistance (MDR)
                     transporters of the Major Facilitator Superfamily;
                     cd17321"
                     /db_xref="CDD:340879"
     Site            order(28..29,32..33,36,68,118..119,121..123,126,146,
                     149..150,153,279,282..283,286..288,318,322,376..377,381,
                     385,401,404..405,408..409,412)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340879"
ORIGIN      
        1 mstvtisdtp fvgndrllvg ivlsvltfwl faqsvinvvp amissldisl etltlavsls
       61 alfsgcfvva sggladkfgr mrmttiglgl sivgsamlvv aqgpglflag rvlqglsaac
      121 impatlalik twyegrarqr avsfwvigsw ggsglcsfvg gaiatglgwr wifvfsiava
      181 llalfllrgt pesrsasasq hkldvgglls livalvlvnl fiskghgwgw ssplsltmla
      241 galaagtifi rngmrkgeaa lidfalfrnr aygaavlsnf llngaigtmm iasiwlqqgh
      301 hltplesgmm tlgylvtvla mirvgekllq rygarlpmma gpvltaiaia lisctfleka
      361 lyigvvfasn vlfglglgcy atpstdtava napenkigva sgiykmgssl ggamgiavta
      421 slfalflplg mahaaqyalw fnavlclgam avsalllpra shs