MULTISPECIES: bifunctional indole-3-glycerol-phosphate synthase

LOCUS       WP_002901733             452 aa            linear   BCT 13-MAY-2021
            TrpC/phosphoribosylanthranilate isomerase TrpF [Klebsiella].
ACCESSION   WP_002901733
VERSION     WP_002901733.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Eberhard,M. and Kirschner,K.
  TITLE     Modification of a catalytically important residue of
            indoleglycerol-phosphate synthase from Escherichia coli
  JOURNAL   FEBS Lett. 245 (1-2), 219-222 (1989)
   PUBMED   2494074
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Priestle,J.P., Grutter,M.G., White,J.L., Vincent,M.G., Kania,M.,
            Wilson,E., Jardetzky,T.S., Kirschner,K. and Jansonius,J.N.
  TITLE     Three-dimensional structure of the bifunctional enzyme
            N-(5'-phosphoribosyl)anthranilate
            isomerase-indole-3-glycerol-phosphate synthase from Escherichia
            coli
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (16), 5690-5694 (1987)
   PUBMED   3303031
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF006945.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09427
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..452
                     /gene="trpCF"
     Protein         1..452
                     /product="bifunctional indole-3-glycerol-phosphate
                     synthase TrpC/phosphoribosylanthranilate isomerase TrpF"
                     /EC_number="4.1.1.48"
                     /EC_number="5.3.1.24"
                     /GO_function="GO:0004425 - indole-3-glycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0004640 - phosphoribosylanthranilate
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0006568 - tryptophan metabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=49168
     Region          1..452
                     /region_name="PRK09427"
                     /note="bifunctional indole-3-glycerol-phosphate synthase
                     TrpC/phosphoribosylanthranilate isomerase TrpF"
                     /db_xref="CDD:236509"
ORIGIN      
        1 mqtvlakiva dkaiwveark qqqplasfqn eivptqrnfy dalagtrtaf ileckkasps
       61 kgliredfdp aaiasiykhy asaisvlcde kyfqgsfdfl pivsqvapqp ilckdftidp
      121 yqiylaryyq adacllmlsv lddeqyrqls avahslnmgv ltevsneeel eraialkakv
      181 vginnrdlrd msidlnrtrq laarlgpdvt visesgihty aevrelshfa ngfligsalm
      241 eqadleaavk rvllgenkvc gltrpqdaqv awesgaiygg lifvptspra vndaqakavi
      301 aaaplqyvgv frnapleevv araqalglaa vqlhgdedqa yidalrdala dnvriwkals
      361 vgetfpartl hhvdkylldn gqggsgqrfd wsllqgqdlr nvmlagglga dncveaaksg
      421 cagldfnsgv esqpgmkdas klasvfqtlr ay