MULTISPECIES: tryptophan synthase subunit alpha [Klebsiella].

LOCUS       WP_002901728             269 aa            linear   BCT 20-NOV-2023
ACCESSION   WP_002901728
VERSION     WP_002901728.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 269)
  AUTHORS   Dunn,M.F.
  TITLE     Allosteric regulation of substrate channeling and catalysis in the
            tryptophan synthase bienzyme complex
  JOURNAL   Arch Biochem Biophys 519 (2), 154-166 (2012)
   PUBMED   22310642
REFERENCE   2  (residues 1 to 269)
  AUTHORS   Hyde,C.C., Ahmed,S.A., Padlan,E.A., Miles,E.W. and Davies,D.R.
  TITLE     Three-dimensional structure of the tryptophan synthase alpha 2 beta
            2 multienzyme complex from Salmonella typhimurium
  JOURNAL   J Biol Chem 263 (33), 17857-17871 (1988)
   PUBMED   3053720
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00262.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..269
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..269
                     /gene="trpA"
     Protein         1..269
                     /product="tryptophan synthase subunit alpha"
                     /EC_number="4.2.1.20"
                     /GO_function="GO:0004834 - tryptophan synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=28413
     Region          8..263
                     /region_name="trpA"
                     /note="tryptophan synthase, alpha subunit; TIGR00262"
                     /db_xref="CDD:161792"
     Site            order(49,60,64,175,183..184,212..213,234..235)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:240075"
     Site            order(49,60,102,183)
                     /site_type="active"
                     /db_xref="CDD:240075"
     Site            order(49,60,102)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:240075"
     Site            order(54..57,59,62,65..66,104,107,129..130,132,135,155,
                     157..159,162)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:240075"
ORIGIN      
        1 meryetlfaq lknrqegafv pfvtlgdpgp eqslkiidal ieggadalel gipfsdplad
       61 gptiqgaalr afaagvtpaq cfemlaairq khptipigll myanlvfspg idafyaqcar
      121 vgvdsvlvad vpveesapfr qaamrhniap ificppnadd dllrqiasyg rgytyllsra
      181 gvtgaenraa lplhhlvekl aeyhaapplq gfgisapeqv saaidagaag aisgsaivki
      241 ierhldepqt mldelkafvq slkaatkta