MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002901278             452 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_002901278
VERSION     WP_002901278.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 452)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022776
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..452
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=49973
     Region          24..433
                     /region_name="MFS_SV2_like"
                     /note="Metazoan Synaptic vesicle glycoprotein 2 (SV2) and
                     related small molecule transporters of the Major
                     Facilitator Superfamily; cd17316"
                     /db_xref="CDD:340874"
     Site            order(34..35,38..39,42,74,124..125,127..129,132,152,
                     155..156,159,270,273..274,277..279,282,309,313,363..364,
                     368,372,388,391..392,395..396,399)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340874"
ORIGIN      
        1 meqcdpigar ldrlplsrfh frifgiisfs llitgflsys gnvvlaklvs ngwsnnylna
       61 aftsalmfgy figsltggfi gdylgrrkaf rlnllivgis acvatfvpnm ywlifcrclm
      121 gcgmgalimi gyasftefip pavrgkwsar lsfvgnwspm lsaaigivvi aflswrimfl
      181 lggaamllaw ylsgryfies prwlagkgqr saaekhlqqv esqiekekni ilpawqsaeh
      241 raevgvesgs fwllfkghml rrtlvaitvl iamnislyti tvwiptifvn sgidvtksil
      301 mtaiimigap vgifiaalii drfprrlfgs slliiiallg yfysiqtaew ailsyglvmi
      361 fflymyvcfa savyvpelwp thlrlrgsgf vnavgrivav ftpygvavll trsgaitvfm
      421 vlgvmlvlca lilfcfgiet rkisleeist la