Sir2 family NAD+-dependent deacetylase [Klebsiella pneumoniae].

LOCUS       WP_002900903             243 aa            linear   BCT 03-OCT-2023
ACCESSION   WP_002900903
VERSION     WP_002900903.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 243)
  AUTHORS   Mishra,P., Beura,S., Sikder,S., Dhal,A.K., Vasudevan,M., Roy,M.,
            Rakshit,J., Budhwar,R., Kundu,T.K. and Modak,R.
  TITLE     vp1524, a Vibrio parahaemolyticus NAD +-dependent deacetylase,
            regulates host response during infection by induction of host
            histone deacetylation
  JOURNAL   J Biochem 171 (6), 673-693 (2022)
   PUBMED   35325168
REFERENCE   2  (residues 1 to 243)
  AUTHORS   Zhao,K., Chai,X. and Marmorstein,R.
  TITLE     Structure and substrate binding properties of cobB, a Sir2 homolog
            protein deacetylase from Escherichia coli
  JOURNAL   J Mol Biol 337 (3), 731-741 (2004)
   PUBMED   15019790
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF001755.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK00481
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Klebsiella pneumoniae"
                     /db_xref="taxon:573"
     gene            1..243
                     /gene="cobB"
     Protein         1..243
                     /product="Sir2 family NAD+-dependent deacetylase"
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /calculated_mol_wt=26598
     Region          6..239
                     /region_name="PRK00481"
                     /note="NAD-dependent deacetylase; Provisional"
                     /db_xref="CDD:234777"
     Site            order(18,20..21,28..29,78,97..98,100,115,182,187,209..210,
                     225)
                     /site_type="other"
                     /note="NAD+ binding site [chemical binding]"
                     /db_xref="CDD:238703"
     Site            order(99,115,156,158..161,186..188)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238703"
     Site            order(123,126,142,145)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238703"
ORIGIN      
        1 mkpeamakpr vvvltgagis aesgiktfra adglweehrv edvatpegfa rdpalvqafy
       61 narrrqlqsp eiapnaahla larledllgd hfllvtqnid nlheragnrr vihmhgellk
      121 vrcswsgqvl ewtgdvtaed kchccqfpaa lrphvvwfge mplgmdeiys aladadifia
      181 igtsghvypa agfvhearlh gahtvelnle psqvgsefae khyglasevv pafidkllqe
      241 nal