MULTISPECIES: sensor histidine kinase [Klebsiella].

LOCUS       WP_002896382             490 aa            linear   BCT 18-FEB-2025
ACCESSION   WP_002896382
VERSION     WP_002896382.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 490)
  AUTHORS   Ortet,P., Whitworth,D.E., Santaella,C., Achouak,W. and Barakat,M.
  TITLE     P2CS: updates of the prokaryotic two-component systems database
  JOURNAL   Nucleic Acids Res 43 (Database issue), D536-D541 (2015)
   PUBMED   25324303
REFERENCE   2  (residues 1 to 490)
  AUTHORS   Attwood,P.V.
  TITLE     Histidine kinases from bacteria to humans
  JOURNAL   Biochem Soc Trans 41 (4), 1023-1028 (2013)
   PUBMED   23863173
REFERENCE   3  (residues 1 to 490)
  AUTHORS   Dutta,R. and Inouye,M.
  TITLE     GHKL, an emergent ATPase/kinase superfamily
  JOURNAL   Trends Biochem Sci 25 (1), 24-28 (2000)
   PUBMED   10637609
REFERENCE   4  (residues 1 to 490)
  AUTHORS   Stock,A.M., Robinson,V.L. and Goudreau,P.N.
  TITLE     Two-component signal transduction
  JOURNAL   Annu Rev Biochem 69, 183-215 (2000)
   PUBMED   10966457
REFERENCE   5  (residues 1 to 490)
  AUTHORS   Stock,J.
  TITLE     Signal transduction: Gyrating protein kinases
  JOURNAL   Curr Biol 9 (10), R364-R367 (1999)
   PUBMED   10339418
REFERENCE   6  (residues 1 to 490)
  AUTHORS   Alex,L.A. and Simon,M.I.
  TITLE     Protein histidine kinases and signal transduction in prokaryotes
            and eukaryotes
  JOURNAL   Trends Genet 10 (4), 133-138 (1994)
   PUBMED   8029829
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 19948164
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..490
                     /product="sensor histidine kinase"
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /calculated_mol_wt=54393
     Region          4..489
                     /region_name="cztS_silS_copS"
                     /note="heavy metal sensor kinase; TIGR01386"
                     /db_xref="CDD:273593"
     Region          254..490
                     /region_name="KdpD"
                     /note="K+-sensing histidine kinase KdpD [Signal
                     transduction mechanisms]; COG2205"
                     /db_xref="CDD:441807"
ORIGIN      
        1 mirrlslsqr lalvvvsllm lcavavcavq lhssaqygna mvqrlssgla qqivarepll
       61 dahgevnrqt lkslfdrlmt fnpsvelyll spdgdllada appghiqrqr idmapvqafl
      121 tgsaspvygd dprspdgrkv fsaaplrvdg qlrgylyiil qgetfnqlaa dawqktlwsi
      181 vlwtlllval fgllagglaw fwvtrpvrll taqvaasgqd sisaiktlaa rrpeprpgne
      241 vavlenrfid larqiadqwd rladsdrqrr efvanishdl rtpltsllgy letltlkdew
      301 ltaeerrqyl tialrqgnkv rhlsqqlfel arlehggikp qrerfamgel isdvaqkfel
      361 tartrevnlh idvpgplpli nadvsmierv vtnlldnamr htpvggeirl avwqenqqlq
      421 vevadngagv daalrddlfq rpsalstqas redrgglgll ivkrmlelhg gdirlvesvs
      481 garfrffvpl