MULTISPECIES: 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

LOCUS       WP_002896378             375 aa            linear   BCT 17-JUN-2024
            [Klebsiella].
ACCESSION   WP_002896378
VERSION     WP_002896378.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 375)
  AUTHORS   Madsen,C.T., Mengel-Jorgensen,J., Kirpekar,F. and Douthwaite,S.
  TITLE     Identifying the methyltransferases for m(5)U747 and m(5)U1939 in
            23S rRNA using MALDI mass spectrometry
  JOURNAL   Nucleic Acids Res 31 (16), 4738-4746 (2003)
   PUBMED   12907714
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR02085.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..375
                     /gene="rlmC"
     Protein         1..375
                     /product="23S rRNA (uracil(747)-C(5))-methyltransferase
                     RlmC"
                     /EC_number="2.1.1.189"
                     /GO_function="GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016070 - RNA metabolic process [Evidence
                     IEA]"
                     /calculated_mol_wt=41440
     Region          2..373
                     /region_name="AdoMet_MTases"
                     /note="S-adenosylmethionine-dependent methyltransferases
                     (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
                     that use S-adenosyl-L-methionine (SAM or AdoMet) as a
                     substrate for methyltransfer, creating the product
                     S-adenosyl-L-homocysteine (AdoHcy); cl17173"
                     /db_xref="CDD:473071"
     Site            order(239..245,261..262,287..289,306)
                     /site_type="other"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]"
                     /db_xref="CDD:100107"
ORIGIN      
        1 mhcalydagr crscqwlerp vpqqladkma dlrtllaaip vaawgepvsg peaafrnkak
       61 mvvsgsverp llgmlhrdgt pvdltdcply paefapvfaa lkpfiaragl tpynvarkrg
      121 elkyllltas qqgemmlrfv lrseakvaql raalpwlqaq lpqlsvitan iqpvhmaime
      181 geqeiffteq qalgevfngv plwirpqsff qtnpavasrl yatardwvra lpvqhmwdlf
      241 cgvggfglhc atptmrltgi eiapeaiaca rqsaaqlgls nlhfqaldst qfatheadap
      301 qlvlvnpprr gigaelcdyl srmappyiiy sscnartmat diarlsgyrv ervqlfdmfp
      361 htahyevltl lvrev