MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002895749             443 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_002895749
VERSION     WP_002895749.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 443)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 443)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 443)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022908
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..443
                     /product="MFS transporter"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48023
     Region          18..439
                     /region_name="MFS_ExuT_GudP_like"
                     /note="Hexuronate transporter, Glucarate transporter, and
                     similar transporters of the Major Facilitator Superfamily;
                     cd17319"
                     /db_xref="CDD:340877"
     Site            order(32..33,36..37,40,72,122..123,125..127,130,150,
                     153..154,157,268,271..272,275..277,280,308,312,365..366,
                     370,374,390,393..394,397..398,401)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340877"
ORIGIN      
        1 msridtlvct darktkyrfv vltmiflvya inyadrtnig avlpfiidef hinnfeagai
       61 asmfflgyav sqipagffia krgtrglvsl sifgfsaftw lmgtvssvfg lklvrlglgl
      121 segpcpvgla stinnwfppk ekatatgvyi aatmfapiiv pplavwiavt wgwrwvffsf
      181 aipgivaaia wyllvkskpa esgfvsqsel aeinagresh nnsvrenili aerftwldki
      241 irvkkmapid takglftskn ilgdclayfm mvsvlygllt wiplylvker gfdvmsmgfv
      301 asmpciggfi gaigggwvsd kllgrrrkpt mmftavstvv mmlimlnipa stlavciglf
      361 fvgfclnigw paftaygmav sdsktypias siinsggnlg gfvapmaagf lldktgsfns
      421 vftyfgicaa iglvvilfld epq