MULTISPECIES: lysylphosphatidylglycerol synthase domain-containing

LOCUS       WP_002895728             321 aa            linear   BCT 02-MAR-2025
            protein [Klebsiella].
ACCESSION   WP_002895728
VERSION     WP_002895728.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 321)
  AUTHORS   Staubitz,P., Neumann,H., Schneider,T., Wiedemann,I. and Peschel,A.
  TITLE     MprF-mediated biosynthesis of lysylphosphatidylglycerol, an
            important determinant in staphylococcal defensin resistance
  JOURNAL   FEMS Microbiol Lett 231 (1), 67-71 (2004)
   PUBMED   14769468
REFERENCE   2  (residues 1 to 321)
  AUTHORS   Kristian,S.A., Durr,M., Van Strijp,J.A., Neumeister,B. and
            Peschel,A.
  TITLE     MprF-mediated lysinylation of phospholipids in Staphylococcus
            aureus leads to protection against oxygen-independent neutrophil
            killing
  JOURNAL   Infect Immun 71 (1), 546-549 (2003)
   PUBMED   12496209
REFERENCE   3  (residues 1 to 321)
  AUTHORS   Peschel,A., Jack,R.W., Otto,M., Collins,L.V., Staubitz,P.,
            Nicholson,G., Kalbacher,H., Nieuwenhuizen,W.F., Jung,G.,
            Tarkowski,A., van Kessel,K.P. and van Strijp,J.A.
  TITLE     Staphylococcus aureus resistance to human defensins and evasion of
            neutrophil killing via the novel virulence factor MprF is based on
            modification of membrane lipids with l-lysine
  JOURNAL   J Exp Med 193 (9), 1067-1076 (2001)
   PUBMED   11342591
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF015651.6
            Evidence Source    :: EMBL-EBI
            Source Identifier  :: PF03706.18
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..321
                     /product="lysylphosphatidylglycerol synthase
                     domain-containing protein"
                     /calculated_mol_wt=35997
     Region          8..>306
                     /region_name="bifunc_MprF"
                     /note="bifunctional lysylphosphatidylglycerol
                     flippase/synthetase MprF; NF033480"
                     /db_xref="CDD:468043"
ORIGIN      
        1 mskshprwrm akrvltvlff iavivllviy aqkvdwqdvw kvirgydrla lfsaialviv
       61 syliygcydl lgraycghkl akrqvmlvsf icyafnltls twvggigmry rlysrlglng
      121 stitrifsls ittnwlgyil lggviftadl vklpphwyis qttlriiggv mliltlcylf
      181 gcafakrrhl tikgqrlvlp swrfallqmg lsaanwmamg aiiwlllgse inyflvlgvl
      241 lvssiagvii hipagigvle avfiamlsge diskgaiiaa llawralyyf lplllatvay
      301 lllesrakkl rqknqrklar e