MULTISPECIES: SDR family NAD(P)-dependent oxidoreductase

LOCUS       WP_002893192             254 aa            linear   BCT 01-MAR-2025
            [Klebsiella].
ACCESSION   WP_002893192
VERSION     WP_002893192.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 254)
  AUTHORS   Yamashita,A., Kato,H., Wakatsuki,S., Tomizaki,T., Nakatsu,T.,
            Nakajima,K., Hashimoto,T., Yamada,Y. and Oda,J.
  TITLE     Structure of tropinone reductase-II complexed with NADP+ and
            pseudotropine at 1.9 A resolution: implication for stereospecific
            substrate binding and catalysis
  JOURNAL   Biochemistry 38 (24), 7630-7637 (1999)
   PUBMED   10387002
REFERENCE   2  (residues 1 to 254)
  AUTHORS   Benach,J., Atrian,S., Gonzalez-Duarte,R. and Ladenstein,R.
  TITLE     The refined crystal structure of Drosophila lebanonensis alcohol
            dehydrogenase at 1.9 A resolution
  JOURNAL   J Mol Biol 282 (2), 383-399 (1998)
   PUBMED   9735295
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF012334.6
            Evidence Source    :: EMBL-EBI
            Source Identifier  :: PF00106.31
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..254
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /calculated_mol_wt=27045
     Region          7..251
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(11,13..14,16,35..37,87..89,139..141,154,158,
                     184..187)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187604"
     Site            order(112,141,154,158)
                     /site_type="active"
                     /db_xref="CDD:187604"
ORIGIN      
        1 matsnvvfit gatsgfgeaa aqvfadagws lvlsgrrypr lkalqdrlaa rvpvhiield
       61 vrdseavaaa vaslpadfad ittlinnagl alsplpaqev aledwktmid tnvtglvtvt
      121 hallptlirh gagasiinig siagqwpypg shvygaskaf vkqfsynlrc dllgtgvrvt
      181 dlapgiaete ftlvrtkgdq aasdklyrgt tplsasdiae qmfyiatlpa hmninrvevm
      241 pvrqawqpfa idrd