MULTISPECIES: bifunctional UDP-sugar hydrolase/5'-nucleotidase UshA

LOCUS       WP_002892203             550 aa            linear   BCT 20-NOV-2023
            [Klebsiella].
ACCESSION   WP_002892203
VERSION     WP_002892203.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 550)
  AUTHORS   Krug,U., Patzschke,R., Zebisch,M., Balbach,J. and Strater,N.
  TITLE     Contribution of the two domains of E. coli 5'-nucleotidase to
            substrate specificity and catalysis
  JOURNAL   FEBS Lett 587 (5), 460-466 (2013)
   PUBMED   23333297
REFERENCE   2  (residues 1 to 550)
  AUTHORS   Alves-Pereira,I., Canales,J., Cabezas,A., Cordero,P.M., Costas,M.J.
            and Cameselle,J.C.
  TITLE     CDP-alcohol hydrolase, a very efficient activity of the
            5'-nucleotidase/UDP-sugar hydrolase encoded by the ushA gene of
            Yersinia intermedia and Escherichia coli
  JOURNAL   J Bacteriol 190 (18), 6153-6161 (2008)
   PUBMED   18641143
REFERENCE   3  (residues 1 to 550)
  AUTHORS   Knofel,T. and Strater,N.
  TITLE     X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase
            containing a dimetal catalytic site
  JOURNAL   Nat Struct Biol 6 (5), 448-453 (1999)
   PUBMED   10331872
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF007109.1
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09558
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..550
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..550
                     /gene="ushA"
     Protein         1..550
                     /product="bifunctional UDP-sugar hydrolase/5'-nucleotidase
                     UshA"
                     /EC_number="3.1.3.5"
                     /EC_number="3.6.1.45"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0009166 - nucleotide catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=60433
     Region          1..550
                     /region_name="ushA"
                     /note="bifunctional UDP-sugar hydrolase/5'-nucleotidase
                     periplasmic precursor; Reviewed; PRK09558"
                     /db_xref="CDD:236566"
ORIGIN      
        1 mhyfkhsval alfaalslgs lsaqayeqdk tykitilhtn dhhghfwrnd ygeyglaaqk
       61 tlvdgirkev aaeggsvlll sggdintgvp esdlqdaepd frgmnligyd amavgnhefd
      121 nplsvlrqqe kwakfpflsa niyqkstger lfkpwalfkr gglkiavigl ttddtakign
      181 peyftdiefr kpaeeaklvi qelqqnekpd vilatthmgh ydngnhgsna pgdvemarsl
      241 pagslamivg ghsqdpvcma aenkkqvdyv pgtpcapdrq ngiwivqahe wgkyvgradf
      301 efrngemklv hyqlipvnlk kkvtydngqs ervlytpqia enpqmmsllt pfqnkgkaql
      361 qvkigsvngh legdrskvrf vqtnmghlll aaqmarsnad favmsgggir dsieagdity
      421 kdvmkvqpfg nvltyvdmng kevvdyltav aqmkpdsgay pqfanvsfva kdgklndlki
      481 kgepvdpakt yrmatlsfna tggdgypnia dkpgyvntgf idaevlkeyi eknspldaaa
      541 yepkgevswq