MULTISPECIES: multidrug efflux transporter transcriptional

LOCUS       WP_002892080             216 aa            linear   BCT 20-NOV-2023
            repressor AcrR [Klebsiella].
ACCESSION   WP_002892080
VERSION     WP_002892080.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 216)
  AUTHORS   Padilla,E., Llobet,E., Domenech-Sanchez,A., Martinez-Martinez,L.,
            Bengoechea,J.A. and Alberti,S.
  TITLE     Klebsiella pneumoniae AcrAB efflux pump contributes to
            antimicrobial resistance and virulence
  JOURNAL   Antimicrob. Agents Chemother. 54 (1), 177-183 (2010)
   PUBMED   19858254
REFERENCE   2  (residues 1 to 216)
  AUTHORS   Li,M., Gu,R., Su,C.C., Routh,M.D., Harris,K.C., Jewell,E.S.,
            McDermott,G. and Yu,E.W.
  TITLE     Crystal structure of the transcriptional regulator AcrR from
            Escherichia coli
  JOURNAL   J. Mol. Biol. 374 (3), 591-603 (2007)
   PUBMED   17950313
REFERENCE   3  (residues 1 to 216)
  AUTHORS   Li,M., Qiu,X., Su,C.C., Long,F., Gu,R., McDermott,G. and Yu,E.W.
  TITLE     Cloning, expression, purification, crystallization and preliminary
            X-ray diffraction analysis of the regulator AcrR from Escherichia
            coli
  JOURNAL   Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 (Pt 11),
            1150-1152 (2006)
   PUBMED   17077502
REFERENCE   4  (residues 1 to 216)
  AUTHORS   Olliver,A., Valle,M., Chaslus-Dancla,E. and Cloeckaert,A.
  TITLE     Role of an acrR mutation in multidrug resistance of in
            vitro-selected fluoroquinolone-resistant mutants of Salmonella
            enterica serovar Typhimurium
  JOURNAL   FEMS Microbiol. Lett. 238 (1), 267-272 (2004)
   PUBMED   15336432
REFERENCE   5  (residues 1 to 216)
  AUTHORS   Ma,D., Alberti,M., Lynch,C., Nikaido,H. and Hearst,J.E.
  TITLE     The local repressor AcrR plays a modulating role in the regulation
            of acrAB genes of Escherichia coli by global stress signals
  JOURNAL   Mol. Microbiol. 19 (1), 101-112 (1996)
   PUBMED   8821940
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            REFSEQ INFORMATION: The reference sequence is identical to
            ABR75897.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR006714
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..216
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..216
                     /gene="acrR"
     Protein         1..216
                     /product="multidrug efflux transporter transcriptional
                     repressor AcrR"
                     /calculated_mol_wt=24625
     Region          1..212
                     /region_name="PRK10668"
                     /note="DNA-binding transcriptional repressor AcrR;
                     Provisional"
                     /db_xref="CDD:182632"
ORIGIN      
        1 marktkqqar etrqlildva lrlfsqqgvs stslatiaka agvtrgaiyw hfknksdlfn
       61 eiwelsdasi sdleieyrak fpndplsvir eilvyvleat vteerrrlmm eiiyhkcefv
      121 gemtvvqqaq rqlslasyer ieqtlkecia akllpanllt rraavlmrsy lsglmenwlf
      181 apdsfdlhae ardyvaille myqfcptlrg peslsa