MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002891473             454 aa            linear   BCT 23-DEC-2024
ACCESSION   WP_002891473
VERSION     WP_002891473.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 454)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 454)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 454)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   4  (residues 1 to 454)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024277
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..454
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48467
     Region          26..436
                     /region_name="MFS_PcaK_like"
                     /note="4-hydroxybenzoate transporter PcaK and similar
                     transporters of the Major Facilitator Superfamily;
                     cd17365"
                     /db_xref="CDD:340923"
     Site            order(36..37,40..41,44,76,126..127,129..131,134,154,
                     157..158,161,265,268..269,272..274,277,304,308,358..359,
                     363,367,383,386..387,390..391,394)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340923"
ORIGIN      
        1 mtqtqrldvr elinrnplsr fqkliiflgf cvialdgfdi aimgfiaptl klewgvsnhq
       61 lglvisaali glalgaifsg pladwlgrkk iiinsvfffg fwtiatafsh nveqmmffrf
      121 mtglglgaam pnigtlvsey aperqrsfii tvifcgftfg aaaggfsasw lipqfgwhsl
      181 malggilpll faplliwllp esvrflvikq apaarirail nrlypgqisd nvrfilpaqp
      241 aagnamrivl srqygfgslm lwlvyfmglf lvyilgswlp tlvkavgmtv sqaaimtaiy
      301 qaggtlgslf agwlmdrinp hralgiiyav gglftmamgy aagsfallcm lafisgacln
      361 gantgmnals aryyptqara tgsswmhgvg rigailsafa gaemmalnlp fesvflilgi
      421 paaltvagla akgifaaghp pvastspasv rgas