MULTISPECIES: porphobilinogen synthase [Klebsiella].

LOCUS       WP_002890201             324 aa            linear   BCT 20-NOV-2023
ACCESSION   WP_002890201
VERSION     WP_002890201.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF009923.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK13384
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..324
                     /gene="hemB"
     Protein         1..324
                     /product="porphobilinogen synthase"
                     /EC_number="4.2.1.24"
                     /GO_function="GO:0004655 - porphobilinogen synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0033014 - tetrapyrrole biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=35325
     Region          4..319
                     /region_name="ALAD_PBGS"
                     /note="Porphobilinogen synthase (PBGS), which is also
                     called delta-aminolevulinic acid dehydratase (ALAD),
                     catalyzes the condensation of two 5-aminolevulinic acid
                     (ALA) molecules to form the pyrrole porphobilinogen (PBG),
                     which is the second step in the...; cl00338"
                     /db_xref="CDD:469728"
     Site            order(9,12..13,24,48,51,140..141,168..169,198..200,219,
                     222,228,231..232,250..254,278,296,300,303)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238226"
     Site            order(118,120,122,130,165,195,201,204..205,210,216,220,
                     247,270,273,312)
                     /site_type="active"
                     /db_xref="CDD:238226"
     Site            order(195,247)
                     /site_type="active"
                     /note="Schiff base residues [active]"
                     /db_xref="CDD:238226"
ORIGIN      
        1 mtdlitrprr lrqsaalral feettlslnd lvlpifveee iddykaieam pgvmripeky
       61 lareierian agirsvmtfg ishhtdatgs dtwnenglva rmsrickstv pemivmsdtc
      121 fceytshghc gvlcdhgvdn datlenlgkq avvaaaagad fiapsaamdg qvqairrsld
      181 aagftntaim systkfassf ygpfreaagt alkgdrktyq mspmnrreai reslldeaqg
      241 adclmvkpag ayldilrdir ersdlplgay qvsgeyamik faaqagaide ekvvleslga
      301 ikragadlif syfaldlaek kilr