MULTISPECIES: NADP-dependent succinate-semialdehyde dehydrogenase

LOCUS       WP_002889845             482 aa            linear   BCT 20-NOV-2023
            [Klebsiella].
ACCESSION   WP_002889845
VERSION     WP_002889845.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF008415.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK11241
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..482
                     /gene="gabD"
     Protein         1..482
                     /product="NADP-dependent succinate-semialdehyde
                     dehydrogenase"
                     /GO_function="GO:0009013 - succinate-semialdehyde
                     dehydrogenase [NAD(P)+] activity [Evidence IEA]"
                     /GO_process="GO:0009450 - gamma-aminobutyric acid
                     catabolic process [Evidence IEA]"
                     /calculated_mol_wt=51580
     Region          1..482
                     /region_name="gabD"
                     /note="NADP-dependent succinate-semialdehyde dehydrogenase
                     I; PRK11241"
                     /db_xref="CDD:183050"
     Site            order(68,77,118,121..122,124..132,138..140,145,227,239,
                     243,246,303,307,353,421,423..424,428,430,433,435..441,447,
                     450..451,457,462,474..480)
                     /site_type="other"
                     /note="tetramerization interface [polypeptide binding]"
                     /db_xref="CDD:143421"
     Site            order(153..157,165,180,182..183,231..234,237,240..241,
                     255..257,289,386,388,414,452)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:143421"
     Site            order(157,255,286,289)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143421"
ORIGIN      
        1 mqlndmtlfr qqalidgqwr dapngdviav tnpangeqlg svpkmgadet reaieaanra
       61 lpawraltak eranilrrwf dlmmenqddl arlmtleqgk plaeakgeis yaasfiewfa
      121 eegkriygdt ipghqadkrl lvikqpigvt aaitpwnfpa amitrkagpa laagctmvlk
      181 pasqtpfsal alaelanrag ipagvfnvvt gsagavggel tsnplvrkls ftgsteigrq
      241 lmeqcakdik kvslelggna pfivfddadl dkavegalas kfrnagqtcv canrlyvqdg
      301 vydrfaeklq qaveklrigd glqdgvttgp lidekavakv eehiadaiak gakvvtggkp
      361 halggnffqp tilvnvpdsa kvakeetfgp laplfrfkde adviaqandt efglaayfya
      421 rdlsrvfrvg ealeygiigi ntgiisteva pfggvkasgl gregskygie dyleikymci
      481 gl