MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002889624             396 aa            linear   BCT 28-JUL-2024
ACCESSION   WP_002889624
VERSION     WP_002889624.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 396)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 396)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023516
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..396
                     /product="MFS transporter"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=40999
     Region          5..368
                     /region_name="MFS_NepI_like"
                     /note="Purine ribonucleoside efflux pump NepI and similar
                     transporters of the Major Facilitator Superfamily;
                     cd17324"
                     /db_xref="CDD:340882"
     Site            order(15..16,19..20,23,55,105..106,108..110,113,133,
                     136..137,140,209,212..213,216..218,221,249,253,303..304,
                     308,312,331,334..335,338..339,342)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340882"
ORIGIN      
        1 mplalfalti gafaigttef vivglvptia qqlsislpsa gllvsiyalg vaigapvlta
       61 ltgrmprkql llalmvlfta gnvlawqapg yetlilarll tglahgvffs igstiatslv
      121 akekaasaia imfggltval vtgvpfgtfi gqhfgwretf lavsilgvia lisslilvpn
      181 nipgrasasl rdqmkvlthp rllmiytita lgyggvftaf tflapmmqel agfspsavsw
      241 illgygvsva ignvwggkla dkhgavsalk fifaalvvll lvfqltasvh yaalatvlvm
      301 gifafgnvpg lqvyvvqkae qytpgavdva sglniaafnv gialgsivgg qtveryglaq
      361 tpwigamivl valllvvlsg rldklprrsa alspeg