MULTISPECIES: 1-deoxy-D-xylulose-5-phosphate reductoisomerase

LOCUS       WP_002889310             400 aa            linear   BCT 28-MAR-2022
            [Klebsiella].
ACCESSION   WP_002889310
VERSION     WP_002889310.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 400)
  AUTHORS   Haymond,A., Johny,C., Dowdy,T., Schweibenz,B., Villarroel,K.,
            Young,R., Mantooth,C.J., Patel,T., Bases,J., San Jose,G.,
            Jackson,E.R., Dowd,C.S. and Couch,R.D.
  TITLE     Kinetic characterization and allosteric inhibition of the Yersinia
            pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP
            synthase)
  JOURNAL   PLoS One 9 (8), e106243 (2014)
   PUBMED   25171339
  REMARK    Publication Status: Online-Only
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF003938.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK05447
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..400
                     /gene="ispC"
     Protein         1..400
                     /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase"
                     /EC_number="1.1.1.267"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0030604 - 1-deoxy-D-xylulose-5-phosphate
                     reductoisomerase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070402 - NADPH binding [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=43132
     Region          1..396
                     /region_name="Dxr"
                     /note="1-deoxy-D-xylulose 5-phosphate reductoisomerase
                     [Lipid transport and metabolism]; COG0743"
                     /db_xref="CDD:440506"
ORIGIN      
        1 mkqltvlgst gsigcstldv vrhnpgrfsv aalvagknvd rmveqcleft pryavmddaq
       61 saerlrtrlh ehgsrtevls gqqaaaevaa ldevdqvmaa ivgaaglvpt laairagktv
      121 llankeslvt cgrlfmeavq qsgarllpvd sehnaifqsm petiqqhlgy adlarngvss
      181 illtgsggpf retavaelaa mtpdqacrhp nwsmgrkisv dsatmmnkgl eyiearwlfn
      241 asaqqmevli hpqsvihsmv ryqdgsvlaq lgepdmrtpi ahtmgwpqrl nsgvkpldfc
      301 qlsnlsfsap dytrypclkl amdafdvgqa atttlnaane esvaaflhgd irftdiaavn
      361 lavldkmdlq epqsiddvlv idaearaiah qqlqrlvaqa