MULTISPECIES: glutamine-hydrolyzing carbamoyl-phosphate synthase

LOCUS       WP_002888051             382 aa            linear   BCT 04-JUN-2024
            small subunit [Klebsiella].
ACCESSION   WP_002888051
VERSION     WP_002888051.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 382)
  AUTHORS   Thoden,J.B., Huang,X., Kim,J., Raushel,F.M. and Holden,H.M.
  TITLE     Long-range allosteric transitions in carbamoyl phosphate synthetase
  JOURNAL   Protein Sci 13 (9), 2398-2405 (2004)
   PUBMED   15322282
REFERENCE   2  (residues 1 to 382)
  AUTHORS   Miles,B.W., Thoden,J.B., Holden,H.M. and Raushel,F.M.
  TITLE     Inactivation of the amidotransferase activity of carbamoyl
            phosphate synthetase by the antibiotic acivicin
  JOURNAL   J Biol Chem 277 (6), 4368-4373 (2002)
   PUBMED   11729189
REFERENCE   3  (residues 1 to 382)
  AUTHORS   Thoden,J.B., Raushel,F.M., Benning,M.M., Rayment,I. and Holden,H.M.
  TITLE     The structure of carbamoyl phosphate synthetase determined to 2.1 A
            resolution
  JOURNAL   Acta Crystallogr D Biol Crystallogr 55 (Pt 1), 8-24 (1999)
   PUBMED   10089390
REFERENCE   4  (residues 1 to 382)
  AUTHORS   Thoden,J.B., Holden,H.M., Wesenberg,G., Raushel,F.M. and Rayment,I.
  TITLE     Structure of carbamoyl phosphate synthetase: a journey of 96 A from
            substrate to product
  JOURNAL   Biochemistry 36 (21), 6305-6316 (1997)
   PUBMED   9174345
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01368.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..382
                     /gene="carA"
     Protein         1..382
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /EC_number="6.3.5.5"
                     /GO_function="GO:0004088 - carbamoyl-phosphate synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0006541 - glutamine metabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=41041
     Region          1..375
                     /region_name="CarA"
                     /note="Carbamoylphosphate synthase small subunit [Amino
                     acid transport and metabolism, Nucleotide transport and
                     metabolism]; COG0505"
                     /db_xref="CDD:440271"
ORIGIN      
        1 miksallvle dgtqfhgrai gatgtavgev vfntsmtgyq eiltdpsysr qivtltyphi
       61 gnvgtnaade essqvhaqgl virdlplias nfrstedlss ylkrhnivai adidtrkltr
      121 llrekgaqng ciiagdspda qlalekakaf pglngmdlak evttaetysw tqgswtlagd
      181 lpeakaesel pfhvvaydfg akrnilrmlv drgcrltvvp akasaadvla lnpdgiflsn
      241 gpgdpapcdy aieaiekfle tdipvfgicl ghqllalasg aktikmkfgh hggnhpvkdi
      301 dnnvvmitaq nhgfavdeat lpanlrvthk slfdgtlqgi hrtdkpafsf qghpeaspgp
      361 hdaaplfdhf ielielyrqs ak