MULTISPECIES: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

LOCUS       WP_002887979             316 aa            linear   BCT 24-MAR-2022
            [Klebsiella].
ACCESSION   WP_002887979
VERSION     WP_002887979.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF002188.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK01045
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..316
                     /gene="ispH"
                     /gene_synonym="lytB"
     Protein         1..316
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /GO_process="GO:0050992 - dimethylallyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /calculated_mol_wt=34316
     Region          1..301
                     /region_name="ispH"
                     /note="4-hydroxy-3-methylbut-2-enyl diphosphate reductase;
                     Reviewed; PRK01045"
                     /db_xref="CDD:234893"
     Site            order(12,96,197)
                     /site_type="other"
                     /note="Fe-S cluster binding site [ion binding]"
                     /db_xref="CDD:260116"
     Site            order(15,40..41,73..74,124,126,167..168,224..227,269)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:260116"
     Site            order(124,126,225,227)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:260116"
ORIGIN      
        1 mqillanprg fcagvdrais ivenaltlyg apiyvrhevv hnryvvdslr krgaifieqi
       61 sevpdgaili fsahgvsqav rneaksrdlt vfdatcplvt kvhmevaras rrgeesilig
      121 haghpevegt mgqynnpqgg mylvespedv lklevkndar lsfmtqttls vddtsdvida
      181 lrarfpkivg prkddicyat tnrqeavral aeqadvvlvv gsknssnsnr laelaqrmgk
      241 aayliddasd iqeawvkdaa cvgvtagasa pdilvqnvit rlqelgggea vplegreeni
      301 vfevpkelrv dvreve