MULTISPECIES: GGDEF domain-containing protein

LOCUS       WP_002887653             348 aa            linear   BCT 31-DEC-2024
            [Gammaproteobacteria].
ACCESSION   WP_002887653
VERSION     WP_002887653.1
KEYWORDS    RefSeq.
SOURCE      Gammaproteobacteria
  ORGANISM  Gammaproteobacteria
            Bacteria; Pseudomonadati; Pseudomonadota.
REFERENCE   1  (residues 1 to 348)
  AUTHORS   Cotter,P.A. and Stibitz,S.
  TITLE     c-di-GMP-mediated regulation of virulence and biofilm formation
  JOURNAL   Curr Opin Microbiol 10 (1), 17-23 (2007)
   PUBMED   17208514
REFERENCE   2  (residues 1 to 348)
  AUTHORS   Simm,R., Fetherston,J.D., Kader,A., Romling,U. and Perry,R.D.
  TITLE     Phenotypic convergence mediated by GGDEF-domain-containing proteins
  JOURNAL   J Bacteriol 187 (19), 6816-6823 (2005)
   PUBMED   16166544
  REMARK    Erratum:[J Bacteriol. 2006 Mar;188(5):2024]
REFERENCE   3  (residues 1 to 348)
  AUTHORS   Chan,C., Paul,R., Samoray,D., Amiot,N.C., Giese,B., Jenal,U. and
            Schirmer,T.
  TITLE     Structural basis of activity and allosteric control of diguanylate
            cyclase
  JOURNAL   Proc Natl Acad Sci U S A 101 (49), 17084-17089 (2004)
   PUBMED   15569936
REFERENCE   4  (residues 1 to 348)
  AUTHORS   Pei,J. and Grishin,N.V.
  TITLE     GGDEF domain is homologous to adenylyl cyclase
  JOURNAL   Proteins 42 (2), 210-216 (2001)
   PUBMED   11119645
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10112692
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Gammaproteobacteria"
                     /db_xref="taxon:1236"
     Protein         1..348
                     /product="GGDEF domain-containing protein"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0052621 - diguanylate cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /calculated_mol_wt=39459
     Region          190..343
                     /region_name="GGDEF"
                     /note="Diguanylate-cyclase (DGC) or GGDEF domain; cd01949"
                     /db_xref="CDD:143635"
     Site            order(224,267)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:143635"
     Site            order(229,232..233,237,241,263,265..268)
                     /site_type="active"
                     /db_xref="CDD:143635"
     Site            order(259,287)
                     /site_type="active"
                     /note="I-site [active]"
                     /db_xref="CDD:143635"
ORIGIN      
        1 mtaqtwrahy aqkyqyslrl flllnfisss lslvtplftv vrftlpcali vvcsgllllw
       61 hwkwpqskin iptisllfgm lwawhvvtka mlltpphfny lviallsilf igtiafsnni
      121 taftlhslpt flaclimaeg eqwlrmtycf mlpiagitlq niiqkrsdaf tqglmdklmh
      181 erntlndlsm ldpltglynr rglqnrldtl laldgdnhyv llldidhfka yndhyghmmg
      241 dqalirvsaa irnavrsrdi varfggeefm vlltnsseet awktaerirq rvydlkiphm
      301 fnesvatnvt isigltplin dnieqalara dgalyeaknk grniilas