MULTISPECIES: MFS transporter [Klebsiella].

LOCUS       WP_002887598             453 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_002887598
VERSION     WP_002887598.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 453)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 453)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 453)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022908
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..453
                     /product="MFS transporter"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=49457
     Region          44..442
                     /region_name="MFS_ExuT_GudP_like"
                     /note="Hexuronate transporter, Glucarate transporter, and
                     similar transporters of the Major Facilitator Superfamily;
                     cd17319"
                     /db_xref="CDD:340877"
     Site            order(54..55,58..59,62,94,144..145,147..149,152,172,
                     175..176,179,266,269..270,273..275,278,306,310,368..369,
                     373,377,393,396..397,400..401,404)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340877"
ORIGIN      
        1 mesqnitidp qtdfkegkae plsvplentl qrssrikkiq ttamillfla avinyldrss
       61 lsvanltirq elglnateig allsvfslay giaqlpcgpl ldrkgpriml glgmffwslf
      121 qalsgmvhsf tqfvlvrigm gigeapmnpc gvkvindwfn ikergrpmgf fnaastigva
      181 vsppilaamm lmmgwrwmfi tigilgifia igwymlyrnr edlpltadeq aylnagsvnv
      241 rrdplsfaew rslfknktmw gmmlgfsgin ytawlylawl pgylqtaynl dlkstgfmaa
      301 ipflfgaagm lingyvtdwl vkggmapiks rkiciiagmf csaaftlivp hattsfaavl
      361 ligmalfcih fagtscwgli hvavasrmta svgsiqnfas ficasfapvv tgfivdtths
      421 fqlalvicgc vtalgalayi flvrqpisdp rnd