MULTISPECIES: SIS domain-containing protein [Klebsiella].

LOCUS       WP_002886940             324 aa            linear   BCT 02-MAR-2025
ACCESSION   WP_002886940
VERSION     WP_002886940.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 324)
  AUTHORS   Bateman,A.
  TITLE     The SIS domain: a phosphosugar-binding domain
  JOURNAL   Trends Biochem Sci 24 (3), 94-95 (1999)
   PUBMED   10203754
REFERENCE   2  (residues 1 to 324)
  AUTHORS   Teplyakov,A., Obmolova,G., Badet-Denisot,M.A., Badet,B. and
            Polikarpov,I.
  TITLE     Involvement of the C terminus in intramolecular nitrogen channeling
            in glucosamine 6-phosphate synthase: evidence from a 1.6 A crystal
            structure of the isomerase domain
  JOURNAL   Structure 6 (8), 1047-1055 (1998)
   PUBMED   9739095
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF013539.6
            Evidence Source    :: EMBL-EBI
            Source Identifier  :: PF01380.27
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..324
                     /product="SIS domain-containing protein"
                     /GO_function="GO:0097367 - carbohydrate derivative binding
                     [Evidence IEA]"
                     /GO_process="GO:1901135 - carbohydrate derivative
                     metabolic process [Evidence IEA]"
                     /calculated_mol_wt=36107
     Region          4..318
                     /region_name="AgaS"
                     /note="Fructoselysine-6-P-deglycase FrlB or related
                     protein, duplicated sugar isomerase (SIS) domain [Cell
                     wall/membrane/envelope biogenesis]; COG2222"
                     /db_xref="CDD:441824"
     Region          23..139
                     /region_name="SIS_1"
                     /note="A subgroup of the SIS domain. SIS (Sugar ISomerase)
                     domains are found in many phosphosugar isomerases and
                     phosphosugar binding proteins. SIS domains are also found
                     in proteins that regulate the expression of genes involved
                     in synthesis of phosphosugars; cd05710"
                     /db_xref="CDD:240214"
     Site            order(31,77)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:240214"
ORIGIN      
        1 mntkeiinav akeiedkggi rqvflvacgg slvdmypaky fldseatklh vgmytanefv
       61 yatpktlgen slvivcshgg ntpesvaaak laqqhqahti tlthnaqaql ieyashnily
      121 awgndtnvvd npmaiilnlc vdtlqqvegf nnyadfqqgm tqingviahg rqqvadrcqr
      181 faqkyqdekl fyilssgasy ghaygfaics lmemqwlhaa pihsgeyfhg pfevtnketp
      241 fillmnegrt ramderalaf ltkyaekvev vdakelgigv lppsvveffn pvlfysimce
      301 yrsaladirq hpldtrrymg lvey