MULTISPECIES: hydroxymethylbilane synthase [Enterobacteriaceae].

LOCUS       WP_002883381             313 aa            linear   BCT 08-FEB-2025
ACCESSION   WP_002883381
VERSION     WP_002883381.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 313)
  AUTHORS   Louie,G.V., Brownlie,P.D., Lambert,R., Cooper,J.B., Blundell,T.L.,
            Wood,S.P., Malashkevich,V.N., Hadener,A., Warren,M.J. and
            Shoolingin-Jordan,P.M.
  TITLE     The three-dimensional structure of Escherichia coli porphobilinogen
            deaminase at 1.76-A resolution
  JOURNAL   Proteins 25 (1), 48-78 (1996)
   PUBMED   8727319
REFERENCE   2  (residues 1 to 313)
  AUTHORS   Fujino,E., Fujino,T., Karita,S., Sakka,K. and Ohmiya,K.
  TITLE     Cloning and sequencing of some genes responsible for porphyrin
            biosynthesis from the anaerobic bacterium Clostridium josui
  JOURNAL   J Bacteriol 177 (17), 5169-5175 (1995)
   PUBMED   7665501
REFERENCE   3  (residues 1 to 313)
  AUTHORS   Hadener,A., Matzinger,P.K., Malashkevich,V.N., Louie,G.V.,
            Wood,S.P., Oliver,P., Alefounder,P.R., Pitt,A.R., Abell,C. and
            Battersby,A.R.
  TITLE     Purification, characterization, crystallisation and X-ray analysis
            of selenomethionine-labelled hydroxymethylbilane synthase from
            Escherichia coli
  JOURNAL   Eur J Biochem 211 (3), 615-624 (1993)
   PUBMED   8436121
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00212.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..313
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..313
                     /gene="hemC"
     Protein         1..313
                     /product="hydroxymethylbilane synthase"
                     /EC_number="2.5.1.61"
                     /GO_function="GO:0004418 - hydroxymethylbilane synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0033014 - tetrapyrrole biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=33670
     Region          4..307
                     /region_name="HemC"
                     /note="Porphobilinogen deaminase [Coenzyme transport and
                     metabolism]; COG0181"
                     /db_xref="CDD:439951"
ORIGIN      
        1 mldkvlkiat rqsplalwqa qyvkarleqa hpglkvelvp mvtrgdvild tplakvggkg
       61 lfvkelelam legradiavh smkdvpvefp eglglvtice rddprdafvs nryasidelp
      121 agsvvgtssl rrqcqlaatr pdlairslrg nvgtrlskld ngeydaiila aaglkrlqle
      181 arirqplspe qslpavgqga vgiecrldda wtrgllapln htetavrvra eramntrleg
      241 gcqvpigsya elkdgelwlr alvgapdgsq lvrgerrgpa eqaealgisl aeelldngar
      301 eilaavydge apr